Title:
Evolutionary Role of DNA Methylation in Animal Genomes
Evolutionary Role of DNA Methylation in Animal Genomes
| dc.contributor.author | Yi, Soojin V. | |
| dc.contributor.corporatename | Georgia Institute of Technology. School of Biology | |
| dc.contributor.corporatename | Georgia Institute of Technology. Institute for Bioengineering and Bioscience | |
| dc.date.accessioned | 2009-04-15T16:34:12Z | |
| dc.date.available | 2009-04-15T16:34:12Z | |
| dc.date.issued | 2008-10-21 | |
| dc.description | Presented on October 21, 2008 from 8:30-9:30 am in IBB Building room 1128 on the Georgia Tech campus. | en |
| dc.description | Runtime: 49:45 minutes | |
| dc.description.abstract | DNA methylation is a primary epigenetic mechanism involved in several regulatory and developmental processes. In this talk, I will focus on the molecular evolutionary role of DNA methylation. An important property of DNA methylation is its propensity to increase specific types of point mutations. Using this property, we have developed analytical tools to investigate influence of DNA methylation on genome evolution. We show that (i) DNA methylation causes different genomic regions to follow qualitatively different molecular clocks, (ii) influence regional variability of nucleotide composition, (iii) affected evolution of vertebrate promoters. Finally, (iv) our survey shows that the influence of DNA methylation on genome evolution is widespread in animal taxa. While the model invertebrate species Drosophila melanogaster and Caenorhabditis elegans lack DNA methylation, the genome of a social bee Apis mellifera exhibits an unmistakable signature of DNA methylation at sequence and functional level. | en |
| dc.format.extent | 49:45 minutes | |
| dc.identifier.uri | http://hdl.handle.net/1853/27647 | |
| dc.language.iso | en_US | en |
| dc.publisher | Georgia Institute of Technology | en |
| dc.relation.ispartofseries | Petit Institute Breakfast Club Seminar Series | |
| dc.subject | DNA methylation | en |
| dc.subject | Genomics | en |
| dc.subject | Animal | en |
| dc.subject | Mutations | en |
| dc.title | Evolutionary Role of DNA Methylation in Animal Genomes | en |
| dc.title.alternative | DNA Methylation and Genome Evolution | |
| dc.type | Moving Image | |
| dc.type | Text | |
| dc.type.genre | Lecture | |
| dc.type.genre | Presentation | |
| dspace.entity.type | Publication | |
| local.contributor.corporatename | Parker H. Petit Institute for Bioengineering and Bioscience | |
| local.relation.ispartofseries | Petit Institute Breakfast Club Seminar Series | |
| relation.isOrgUnitOfPublication | d978f252-ad5a-4fe6-a735-21050b2d760e | |
| relation.isSeriesOfPublication | 037a6ee9-c6f0-4f20-abb8-e229d98f6754 |
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