Title:
Functional molecular imaging in the brain
Functional molecular imaging in the brain
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Author(s)
Jasanoff, Alan
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Abstract
Functional magnetic resonance imaging (fMRI) with contrast agents sensitive to neural activity could have great impact in neuroscience by combining noninvasive whole-brain coverage with
molecular-level specificity for neuronal events. My laboratory is developing molecular fMRI
approaches based on molecular sensors we have designed to detect intra- and extracellular
signalling events in the nervous system. Our sensors are built on a variety of chemical platforms, ranging from small molecules to nanoparticles. Protein-based contrast agents are of particular interest to us because of the possibility of gene-based brain delivery strategies and the availability
of powerful protein engineering techniques. Here we describe molecular engineering of several MRI
sensors for neural activity, as well as the first efforts in our laboratory to perform functional
neuroimaging with molecular specificity in living brains.
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Date Issued
2011-02-24
Extent
64:11 minutes
Resource Type
Moving Image
Resource Subtype
Lecture