The Genomics of Restriction and Modification

Roberts, Richard J.

Title:

The Genomics of Restriction and Modification

dc.contributor.author	Roberts, Richard J.
dc.contributor.corporatename	New England BioLabs
dc.contributor.corporatename	Georgia Institute of Technology. Integrative BioSystems Institute
dc.date.accessioned	2010-10-15T20:22:51Z
dc.date.available	2010-10-15T20:22:51Z
dc.date.issued	2010-10-13
dc.description	Sir Richard J. Roberts, Ph.D. is the 1993 Nobel Prize winner for discovery of the discontinuous nature of eukaryotic genes (exons and introns) and a pioneer in restriction enzyme biochemistry and computational biology. He is the Chief Scientific Officer of New England BioLabs.
dc.description	Runtime: 75:49 minutes
dc.description.abstract	The discovery of new restriction enzymes has progressed from the slow and laborious process of examining individual bacterial strains experimentally to the much higher through-put that can be obtained using bioinformatics to analyze genome sequences. Nevertheless, both the traditional biochemical approach and the use of biochemistry to test bioinformatics predictions are an integral part of current practices. The analysis of bacterial genomes for their content of genes related to restriction-modification systems faces many of the challenges found more generally when annotating genomes. The methodology that we have developed will be described and examples will be drawn from the analysis of both individual microorganisms and the environmental projects that broadly sample various environments. In the final part of the talk, the more general problem of genome annotation will be discussed and a new project, COMBREX, that aims to accelerate the experimental assignment of function to genes will be described.	en_US
dc.format.extent	75:49 minutes
dc.identifier.uri	http://hdl.handle.net/1853/35273
dc.language.iso	en_US	en_US
dc.publisher	Georgia Institute of Technology	en_US
dc.relation.ispartofseries	Distinguished Scientific Leader Lecture
dc.subject	Restriction enzymes	en_US
dc.subject	Genomics	en_US
dc.subject	COMBREX	en_US
dc.title	The Genomics of Restriction and Modification	en_US
dc.type	Moving Image
dc.type.genre	Lecture
dspace.entity.type	Publication
local.contributor.corporatename	Integrative BioSystems Institute
local.relation.ispartofseries	Distinguished Scientific Leader Lecture
relation.isOrgUnitOfPublication	139564d0-ade3-4d4d-8bcc-c5cf8a364b21
relation.isSeriesOfPublication	98a4f688-dbb5-46b3-a9b6-7aa71d7e0ba0