Title:
Gene Based Neuromodulation
Gene Based Neuromodulation
dc.contributor.author | Boulis, Nicholas | |
dc.contributor.corporatename | Georgia Institute of Technology. Institute for Bioengineering and Bioscience | en_US |
dc.contributor.corporatename | Emory University | en_US |
dc.date.accessioned | 2017-03-23T18:43:27Z | |
dc.date.available | 2017-03-23T18:43:27Z | |
dc.date.issued | 2017-03-14 | |
dc.description | Presented on March 14, 2017 from 8:30 a.m.-9:30 a.m. at the Parker H. Petit Institute for Bioengineering and Bioscience (IBB), room 1128, Georgia Tech. | en_US |
dc.description | Nicholas Boulis, M.D. is an Associate Professor in the Department of Neurosurgery, Emory University School of Medicine. | en_US |
dc.description | Runtime: 68:07 minutes | en_US |
dc.description.abstract | Nicholas Boulis, M.D. is a Functional Neurosurgeon with significant expertise in the field of gene transfer to the nervous system. Dr. Boulis' Gene and Cell Therapy Translational Laboratory pursues advanced biological treatments for neurological disorders, including Amyotrophic Lateral Sclerosis (ALS, also known as Lou Gehrig's disease) and Spinal Muscular Atrophy (SMA). Over the last two decades, growing knowledge about the underlying causes of these diseases, as well as the protective effects of special proteins, has given rise to hope for the development of therapies. Dr. Boulis' laboratory specializes in the therapeutic application of the genes for these proteins. Within the Boulis laboratory, the genes for neural growth factors and antiapoptotic intracellular proteins are inserted into the DNA of genetically engineered viruses. These viruses, which have been rendered safe through the removal of their native genes, can be used to transfer therapeutic genes into diseased tissue. A variety of vectors are currently being tested in both neuronal cell cultures and in animal models for MND. In parallel, the Boulis laboratory has focused on the development of tissuespecific targeting strategies. These approaches are designed to deliver molecular therapeutics to an anatomically defined site of interest. Much of this effort has concentrated on motor neuron-specific gene delivery. Finally, Dr. Boulis has focused on the development of techniques for safe and accurate injection of stem cells into the human spinal cord. Research in the Boulis laboratory tests basic principles while providing tools for clinical translation. Techniques/assays applied in the lab include: neuronal cell cultures, rodent transgenic colonies, surgery in rodents (mice and rats), locomotor behavior assays in rodents, surgery in large animals {pigs and monkeys), histology, etc. With proof-of-principle in the laboratory and Dr. Boulis' expertise in neurosurgery, the laboratory creates a unique resource for the development and clinical translation of these concepts. | en_US |
dc.format.extent | 68:07 minutes | |
dc.identifier.uri | http://hdl.handle.net/1853/56545 | |
dc.language.iso | en_US | en_US |
dc.publisher | Georgia Institute of Technology | en_US |
dc.relation.ispartofseries | Petit Institute Breakfast Club Seminar Series | |
dc.subject | Neurotransmitters | en_US |
dc.title | Gene Based Neuromodulation | en_US |
dc.type | Moving Image | |
dc.type.genre | Lecture | |
dspace.entity.type | Publication | |
local.contributor.corporatename | Parker H. Petit Institute for Bioengineering and Bioscience | |
local.relation.ispartofseries | Petit Institute Breakfast Club Seminar Series | |
relation.isOrgUnitOfPublication | d978f252-ad5a-4fe6-a735-21050b2d760e | |
relation.isSeriesOfPublication | 037a6ee9-c6f0-4f20-abb8-e229d98f6754 |
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