Protein Assembly to Create Therapeutic Nanomaterials

Champion, Julie A.

Title:

Protein Assembly to Create Therapeutic Nanomaterials

dc.contributor.author	Champion, Julie A.
dc.contributor.corporatename	Georgia Institute of Technology. Institute for Electronics and Nanotechnology	en_US
dc.contributor.corporatename	Georgia Institute of Technology. School of Chemical and Biomolecular Engineering	en_US
dc.date.accessioned	2017-01-19T20:28:41Z
dc.date.available	2017-01-19T20:28:41Z
dc.date.issued	2017-01-10
dc.description	Presented at the Nano@Tech Meeting on January 10, 2017 at 12:00 p.m. in room 1117-1118 of the Marcus Nanotechnology Building, Georgia Tech.	en_US
dc.description	Julie Champion is an Associate Professor in the School of Chemical & Biomolecular Engineering at Georgia Institute of Technology and a member of the Institute for Bioengineering and Biosciences and the Bioengineering Program. She earned her B.S.E. in Chemical Engineering from the University of Michigan in 2001. Dr. Champion completed her Ph.D. in Chemical Engineering at the University of California Santa Barbara in 2007 as a National Science Foundation graduate fellow under the advisement of Dr. Samir Mitragotri. She was a National Institutes of Health postdoctoral fellow from 2007-2009 at the California Institute of Technology in the lab of Dr. David Tirrell. Professor Champion's current research focuses on design and self-assembly of therapeutic nanomaterials made from engineered proteins for applications in cancer and immunology. Dr. Champion has received a BRIGE award from the National Science Foundation, the Georgia Tech Women in Engineering Faculty Award for Excellence in Teaching, the Georgia Tech BioEngineering Program Outstanding Advisor Award, and the Georgia Tech Outstanding Undergraduate Research Mentor Award.	en_US
dc.description	Runtime: 54:25 minutes	en_US
dc.description.abstract	Protein drugs can provide a key advantage over small molecule drugs; they evolved to perform their function, while small molecules are often selected for “best” function compared to a pool of candidates. However, proteins can present challenges in delivery that must be overcome in order to be used as therapeutic drugs. Their folded structure is critical to their biological function and makes them sensitive and difficult to package. However, this structure also provides an opportunity to create materials from them that is not available for small molecules. The main goal of our work is to engineer materials made from therapeutic proteins and this is accomplished through a combination of self-assembly and/or bioconjugation processes. The ability to control these processes is essential to manipulating material physical properties, ensuring retention of protein activity, and directing the interactions between the materials and cells. The strategies developed here provide opportunities to work with unlikely proteins, such as those from pathogenic bacteria, and transform them from disease causing agents into beneficial therapeutic materials. Protein design, self-assembly and disassembly properties, and applications of therapeutic protein materials in immunomodulation will be discussed.	en_US
dc.format.extent	54:25 minutes
dc.identifier.uri	http://hdl.handle.net/1853/56406
dc.language.iso	en_US	en_US
dc.publisher	Georgia Institute of Technology	en_US
dc.relation.ispartofseries	Nano@Tech Lecture Series
dc.subject	Nanomaterials	en_US
dc.subject	Nanotechnology	en_US
dc.subject	Protein assembly	en_US
dc.subject	Therapeutic proteins	en_US
dc.title	Protein Assembly to Create Therapeutic Nanomaterials	en_US
dc.type	Moving Image
dc.type.genre	Lecture
dspace.entity.type	Publication
local.contributor.author	Champion, Julie A.
local.contributor.corporatename	Institute for Electronics and Nanotechnology (IEN)
local.relation.ispartofseries	Nano@Tech Lecture Series
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