Structural Basis for Iron Piracy by Pathogenic Neisseria

Buchanan, Susan

Title:

Structural Basis for Iron Piracy by Pathogenic Neisseria

dc.contributor.author	Buchanan, Susan
dc.contributor.corporatename	National Institutes of Health (U.S.)
dc.date.accessioned	2012-10-30T18:49:04Z
dc.date.available	2012-10-30T18:49:04Z
dc.date.issued	2012-10-16
dc.description	Susan Buchanan of the National Institutes of Health presented a lecture on Tuesday, October 16, 2012 from 11:00 am to 12:00 pm in the Klaus Advanced Computing Building, Room 1116E.	en_US
dc.description	Runtime: 52:04 minutes.	en_US
dc.description.abstract	Neisseria are obligate human pathogens causing bacterial meningitis, septicemia, and gonorrhea. Neisseria require iron for survival and can extract it directly from human transferrin for transport across the outer membrane. The transport system consists of TbpA, an integral outer membrane protein, and TbpB, a co-receptor attached to the cell surface; both proteins are potentially important vaccine and therapeutic targets. Two key questions driving Neisseria research are: 1) how human transferrin is specifically targeted, and 2) how the bacteria liberate iron from transferrin at neutral pH. To address them, we solved crystal structures of the TbpA-transferrin complex and of the corresponding co-receptor TbpB. We characterized the TbpB-transferrin complex by small angle X-ray scattering and the TbpA-TbpB-transferrin complex by electron microscopy. Collectively, our studies provide a rational basis for the specificity of TbpA for human transferrin, show how TbpA promotes iron release from transferrin, and elucidate how TbpB facilitates this process.	en_US
dc.format.extent	52:04 minutes
dc.identifier.uri	http://hdl.handle.net/1853/45213
dc.language.iso	en_US	en_US
dc.publisher	Georgia Institute of Technology	en_US
dc.subject	Protein crystallography	en_US
dc.subject	Bacterial pathogens	en_US
dc.subject	Host-pathogen interactions	en_US
dc.title	Structural Basis for Iron Piracy by Pathogenic Neisseria	en_US
dc.type	Moving Image
dc.type.genre	Lecture
dspace.entity.type	Publication
local.contributor.corporatename	College of Sciences
local.contributor.corporatename	School of Biological Sciences
local.contributor.corporatename	Center for the Study of Systems Biology
local.relation.ispartofseries	Distinguished Lecture Series in Systems Biology
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