Title:
Using Human Brain Organoids to Unveil Neuron-Glial Interactions During Development
Using Human Brain Organoids to Unveil Neuron-Glial Interactions During Development
| dc.contributor.author | Sloan, Steven A. | |
| dc.contributor.corporatename | Georgia Institute of Technology. Neural Engineering Center | en_US |
| dc.contributor.corporatename | Emory University. Dept. of Human Genetics | en_US |
| dc.date.accessioned | 2019-10-14T14:45:58Z | |
| dc.date.available | 2019-10-14T14:45:58Z | |
| dc.date.issued | 2019-09-23 | |
| dc.description | Presented on September 23, 2019 at 11:15 a.m. in the Krone Engineered Biosystems Building, Room 1005. | en_US |
| dc.description | Dr. Steven Sloan is an Assistant Professor in the Department of Human Genetics, at the Emory University School of Medicine. Steven joined the Emory faculty in the fall of 2018, where his lab studies glial development and the role these cells play in neurodevelopmental and neuropsychiatric disease. | en_US |
| dc.description | Runtime: 57:09 minutes | en_US |
| dc.description.abstract | Glia are the most abundant cell types in the mammalian nervous system. They are integral to normal brain physiology, yet we still understand very little about what functions they perform, how they develop, and how they are involved in disease. We understand even less about these cells in humans because of the lack of direct access to intact, functioning human brain tissue. Our lab is using pluripotent stem cells (iPSCs) derived non-invasively from skin samples to generate brain cells in the lab. Because the brain is a 3D structure and studying cells growing on a plate does not recapitulate its complexity, we are using human iPSCs to generate functional 3D structures that are patterned to mirror specific regions of the human brain. We can culture these 'brains-in-a-dish' for long periods of time to ask how normal brain development is occurring in a human system. Additionally, this method allows us to ask questions about how neurons and glia interact with each other in both healthy and diseased contexts, and to manipulate specific variables of brain development in an otherwise complex developmental system. | en_US |
| dc.format.extent | 57:09 minutes | |
| dc.identifier.uri | http://hdl.handle.net/1853/61923 | |
| dc.language.iso | en_US | en_US |
| dc.relation.ispartofseries | GT Neuro Seminar Series | |
| dc.subject | Brain development | en_US |
| dc.subject | iPSC | en_US |
| dc.subject | Organoid | en_US |
| dc.title | Using Human Brain Organoids to Unveil Neuron-Glial Interactions During Development | en_US |
| dc.type | Moving Image | |
| dc.type.genre | Lecture | |
| dspace.entity.type | Publication | |
| local.contributor.corporatename | Neural Engineering Center | |
| local.relation.ispartofseries | GT Neuro Seminar Series | |
| relation.isOrgUnitOfPublication | c2e26044-257b-4ef6-8634-100dd836a06c | |
| relation.isSeriesOfPublication | 608bde12-7f29-495f-be22-ac0b124e68c5 |
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