In-vivo study of brain tumor migration via electrospun nanofiber implants

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Cho, Jae Sung
Bellamkonda, Ravi V.
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Glioblastoma multiforme (GBM), one of the deadliest forms of human brain cancer, migrates to different parts of the brain via the white matter tracts. This behavior is the basis for biomaterial research currently done to mimic white matter tracts so that GBM migration can be investigated .While there have been many in-vitro studies done on GBM migration with electrospun nanofiber films, only one in-vivo study has been done on GBM migration. Encouraged by our findings on GBM cell migration on aligned fiber films published in Nature Materials, we proposed to make two new implant designs, the aligned conduit implant and the silicone tube implant and utilize these nanofiber films to investigate GBM cell migration from inside the brain to outside of the brain. It was found that the silicone tube implants had a design flaw that hindered GBM cell migration from the tumor. The aligned conduit implant facilitated GBM migration significantly with a p-value of 2.01×10-4. Quantification of migration was done using a recently introduced SeeDB protocol, which greatly expedited analysis time. The results from in this investigation show that it is possible to design a brain implant that is able to remove GBM tumor non-invasively and will add to the advancement to biomedical technology in this field.
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