Title:
In-vivo study of brain tumor migration via electrospun nanofiber implants

dc.contributor.advisor Bellamkonda, Ravi V.
dc.contributor.author Cho, Jae Sung
dc.contributor.department Biomedical Engineering (Joint GT/Emory Department)
dc.date.accessioned 2017-07-28T18:32:32Z
dc.date.available 2017-07-28T18:32:32Z
dc.date.created 2014-12
dc.date.issued 2015-01-28
dc.date.submitted December 2014
dc.date.updated 2017-07-28T18:32:32Z
dc.description.abstract Glioblastoma multiforme (GBM), one of the deadliest forms of human brain cancer, migrates to different parts of the brain via the white matter tracts. This behavior is the basis for biomaterial research currently done to mimic white matter tracts so that GBM migration can be investigated .While there have been many in-vitro studies done on GBM migration with electrospun nanofiber films, only one in-vivo study has been done on GBM migration. Encouraged by our findings on GBM cell migration on aligned fiber films published in Nature Materials, we proposed to make two new implant designs, the aligned conduit implant and the silicone tube implant and utilize these nanofiber films to investigate GBM cell migration from inside the brain to outside of the brain. It was found that the silicone tube implants had a design flaw that hindered GBM cell migration from the tumor. The aligned conduit implant facilitated GBM migration significantly with a p-value of 2.01×10-4. Quantification of migration was done using a recently introduced SeeDB protocol, which greatly expedited analysis time. The results from in this investigation show that it is possible to design a brain implant that is able to remove GBM tumor non-invasively and will add to the advancement to biomedical technology in this field.
dc.description.degree Undergraduate
dc.format.mimetype application/pdf
dc.identifier.uri http://hdl.handle.net/1853/58449
dc.language.iso en_US
dc.publisher Georgia Institute of Technology
dc.subject GBM
dc.subject Brain implant
dc.title In-vivo study of brain tumor migration via electrospun nanofiber implants
dc.type Text
dc.type.genre Undergraduate Thesis
dspace.entity.type Publication
local.contributor.advisor Bellamkonda, Ravi V.
local.contributor.corporatename Wallace H. Coulter Department of Biomedical Engineering
local.contributor.corporatename Undergraduate Research Opportunities Program
local.contributor.corporatename College of Engineering
local.relation.ispartofseries Undergraduate Research Option Theses
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thesis.degree.level Undergraduate
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