dc.contributor.advisor	Prausnitz, Mark R.
dc.contributor.author	Tadros, Andrew
dc.contributor.committeeMember	Arbiser, Jack
dc.contributor.committeeMember	Champion, Julie
dc.contributor.committeeMember	Lam, Wilbur
dc.contributor.committeeMember	Lu, Hang
dc.contributor.department	Chemical and Biomolecular Engineering
dc.date.accessioned	2020-01-14T14:40:21Z
dc.date.available	2020-01-14T14:40:21Z
dc.date.created	2017-12
dc.date.issued	2017-11-14
dc.date.submitted	December 2017
dc.date.updated	2020-01-14T14:40:22Z
dc.description.abstract	Cutaneous delivery of bioactive agents is important for treatment of many medical indications, especially in dermatology. In this work a novel skin penetration enhancement technology, called STAR particles, was designed, fabricated, developed and characterized ex vivo and in vivo. STAR particles are millimeter-scale particles with micro-scale projections that painlessly pierce skin to thereby enhance topical drug delivery. STAR particles were fabricated from biocompatible materials (stainless steel and alumina) and applied to skin similarly to conventional formulation-based skin products. STAR particle functionality was demonstrated and characterized through quantification of gentian violet skin staining; skin electrical resistance; and delivery of topically applied compounds (sulforhodamine B, 4 kDa FITC-Dextran, 5-fluorouracil, methotrexate and bleomycin). After STAR particle pre-treatment, skin electrical resistance decreased by an order of magnitude or greater. Additionally, gentian violet skin staining enabled visualization of the many dozen microscopic skin puncture sites created by STAR particles. STAR particles skin treatment also enhanced cutaneous delivery of molecules by up to 90-fold. The results from these studies demonstrate that STAR particles functioned to increase skin permeability through the formation of microscopic skin punctures. STAR particles were also demonstrated to be safe, tolerable, efficacious and acceptable when applied to skin of healthy human participants. In conclusion, STAR particles can be used as a formulation-based additive in topical therapies to enhance delivery of topically applied therapies. In this way, STAR particles may potentially improve the clinical potential of topically applied drugs and expand the number of biomolecules that can be administered into skin.
dc.description.degree	Ph.D.
dc.format.mimetype	application/pdf
dc.identifier.uri	http://hdl.handle.net/1853/62178
dc.language.iso	en_US
dc.publisher	Georgia Institute of Technology
dc.subject	Drug delivery
dc.subject	Dermatology
dc.subject	Skin
dc.subject	Microneedles
dc.subject	Topicals
dc.title	STAR particles for enhanced cutaneous delivery of topical therapeutics
dc.type	Text
dc.type.genre	Dissertation
dspace.entity.type	Publication
local.contributor.advisor	Prausnitz, Mark R.
local.contributor.corporatename	School of Chemical and Biomolecular Engineering
local.contributor.corporatename	College of Engineering
relation.isAdvisorOfPublication	4bd611de-763a-4e92-abdc-0558443485cc
relation.isOrgUnitOfPublication	6cfa2dc6-c5bf-4f6b-99a2-57105d8f7a6f
relation.isOrgUnitOfPublication	7c022d60-21d5-497c-b552-95e489a06569
thesis.degree.level	Doctoral

Title: STAR particles for enhanced cutaneous delivery of topical therapeutics

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STAR particles for enhanced cutaneous delivery of topical therapeutics