Title:
Fabrication of TiO2 Nano-fiber Meshes by Electrospinning and Evaluation of their Potential for Bone Applications
Fabrication of TiO2 Nano-fiber Meshes by Electrospinning and Evaluation of their Potential for Bone Applications
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Author(s)
Gittens Ibacache, Rolando Arturo
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Abstract
Ideal outcomes in the field of tissue engineering and regenerative medicine involve biomaterials that can enhance cell
differentiation and tissue repair without the use of systemic drugs. Tissue engineering biomaterials include polymeric scaffolds that
mimic the native 3-D structural environment of the final application, but that usually need to be functionalized with proteins or small
peptides to improve their bioactivity. Particularly for bone applications, titanium implants, or more appropriately the titanium dioxide
(TiO2) passive layer formed on their surface, have been shown to enhance osteoblast differentiation in vitro and to promote
osseointegration in vivo. However, few studies have looked at the effect of the structural properties of pure TiO2 porous biomaterials
for tissue engineering. In this study, we evaluated the effect of pure TiO2 nano-fiber meshes prepared by electrospinning, with
different surface roughness and nano-fiber diameters, on osteoblast differentiation.
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Date Issued
2011-04-12
Extent
23:08 minutes
Resource Type
Moving Image
Resource Subtype
Lecture