RNA-based Drugs for Treating Influenza and SARS-CoV-2

Santangelo, Philip J.

Title:

RNA-based Drugs for Treating Influenza and SARS-CoV-2

dc.contributor.author	Santangelo, Philip J.
dc.contributor.corporatename	Georgia Institute of Technology. Institute for Electronics and Nanotechnology	en_US
dc.contributor.corporatename	Georgia Institute of Technology. Department of Biomedical Engineering	en_US
dc.date.accessioned	2020-05-11T20:09:14Z
dc.date.available	2020-05-11T20:09:14Z
dc.date.issued	2020-05-06
dc.description	Presented on May 1, 2020 from 11:00 a.m.-12:00 p.m. online. Spring 2020 NANOFANS Webinar Series: Session 2.	en_US
dc.description	2020 Spring NanoFANS (Focusing on Advanced Nanobio Systems) program will be offered in a weekly webinar format during the month of May 2020. The focus of this event will be “Nanotechnology in Infectious Diseases (Diagnostics/Therapeutics)."	en_US
dc.description	In the current global pandemic situation, infectious diseases are the leading cause of mortality worldwide, with viruses such as, ebola, SARS-Cov, SARS-Cov-2 in particular, making global impact on healthcare and socio-economic development. The rapid development of drug resistance to currently available therapies and associated side effects leads to serious public health concern; hence, devising novel treatment strategies is of paramount importance. The application of nanotechnology in infectious diseases is fast-revolutionizing the biomedical field and the healthcare sector and has a potential to diagnose, treat and prevent diseases."	en_US
dc.description	Dr. Philip J. Santangelo is a Professor in the Wallace H. Coulter Department of Biomedical Engineering. He graduated from Polytechnic University (NY) in 1991 with a B.S. in Aerospace Engineering. In 1998, he obtained his Ph.D. in Engineering from the University of California at Davis under Dr. Ian Kennedy, on the development of laser-based diagnostics for multiphase reacting jets and droplet streams. Dr. Santangelo followed his Ph.D. with a postdoctoral fellowship at Sandia National Laboratories in Livermore, California under Christopher Shaddix, and a position in industry, at Micron Optics, Inc., in Atlanta, Georgia. Next, Dr. Santangelo returned to academia as a postdoctoral fellow and then as a research faculty member at Georgia Tech under Dr. Gang Bao. In 2007 he started as an Assistant Professor in BME and was promoted with tenure in 2013 to Associate Professor and is a professor currently. Dr. Santangelo’s current research focuses on the development of imaging and detection technology for the study of RNA regulation and the pathogenesis of RNA viruses.	en_US
dc.description	Runtime: 55:16 minutes
dc.description.abstract	RNA-based drugs for treating influenza and SARS-CoV-2 will be discussed. In particular, I’ll talk about why we make drugs based on synthetic mRNA and why RNA based drugs make sense for treating infections. In addition, I’ll discuss how my lab has been using mRNA-based Cas13 to target and mitigate influenza virus A (IAV) and SARS-CoV-2. I’ll discuss how we have made strides towards a pan-influenza treatment and show significant mitigation of SARS-CoV-2 in vitro. Last, I’ll talk about how we administer these drugs in vivo and preliminary data demonstrating function.	en_US
dc.format.extent	55:16 minutes
dc.identifier.uri	http://hdl.handle.net/1853/62574
dc.language.iso	en_US	en_US
dc.publisher	Georgia Institute of Technology	en_US
dc.relation.ispartofseries	NanoFANS Forum
dc.subject	Cas13	en_US
dc.subject	COVID-19	en_US
dc.subject	Influenza	en_US
dc.subject	mRNA	en_US
dc.subject	SARS-CoV-2	en_US
dc.title	RNA-based Drugs for Treating Influenza and SARS-CoV-2	en_US
dc.type	Moving Image
dc.type.genre	Lecture
dspace.entity.type	Publication
local.contributor.author	Santangelo, Philip J.
local.contributor.corporatename	Institute for Electronics and Nanotechnology (IEN)
local.relation.ispartofseries	NanoFANS Forum
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