Title:
Dissection of Neural Circuit Function and Degeneration from a Subcellular Perspective
Dissection of Neural Circuit Function and Degeneration from a Subcellular Perspective
| dc.contributor.author | Rowan, Matthew | |
| dc.contributor.corporatename | Georgia Institute of Technology. Neural Engineering Center | en_US |
| dc.contributor.corporatename | Emory University. Dept. of Cell Biology | en_US |
| dc.date.accessioned | 2020-02-24T18:50:53Z | |
| dc.date.available | 2020-02-24T18:50:53Z | |
| dc.date.issued | 2020-02-17 | |
| dc.description | Presented on February 17, 2020 at 11:15 a.m. in the Marcus Nanotechnology Building, Room 1116. | en_US |
| dc.description | Matthew Rowan is an assistant professor at Emory University's School of Medicine. His lab uses a combination of cutting-edge imaging, electrophysiological, optogenetic, and surgical techniques to answer fundamental questions about brain function. Our research aims to uncover how the functional properties of neurons allow for proper learning and behavior, with an emphasis on electrical and chemical signaling within the smallest regions of these cells (dendritic spines and axonal boutons). | en_US |
| dc.description | Runtime: 54:12 minutes | en_US |
| dc.description.abstract | How do neurons perform the set of signaling functions necessary for proper circuit function? We aim to uncover cellular and molecular mechanisms that shape excitability among different mammalian neurons. We approach these questions in intact brain circuits, using intersectional approaches combining optogenetics, in vivo and ex vivo electrophysiology, 2P imaging, AAV vectors, and transgenic models. Perhaps the most critical neuronal signaling features are action potential firing and synaptic transmission. Neurons regulate these features by spatially segregating different ion channels in the soma, dendrites, and axon. We are now beginning to understand the significance of these cellular processes in terms of circuit function and disease. We are interested in understanding how different cell classes, (e.g., inhibitory neurons) utilize these excitable mechanisms to their advantage in the circuit. Knowledge gained from these studies will fuel the design of robust, cell-type-specific therapeutic approaches against neurological disorders. | en_US |
| dc.format.extent | 54:12 minutes | |
| dc.identifier.uri | http://hdl.handle.net/1853/62469 | |
| dc.language.iso | en_US | en_US |
| dc.relation.ispartofseries | GT Neuro Seminar Series | |
| dc.subject | Cortex | en_US |
| dc.subject | Dendrite | en_US |
| dc.subject | Inhibition | en_US |
| dc.title | Dissection of Neural Circuit Function and Degeneration from a Subcellular Perspective | en_US |
| dc.type | Moving Image | |
| dc.type.genre | Lecture | |
| dspace.entity.type | Publication | |
| local.contributor.corporatename | Neural Engineering Center | |
| local.relation.ispartofseries | GT Neuro Seminar Series | |
| relation.isOrgUnitOfPublication | c2e26044-257b-4ef6-8634-100dd836a06c | |
| relation.isSeriesOfPublication | 608bde12-7f29-495f-be22-ac0b124e68c5 |
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