Title:
Spatial Distribution of Serotonergic Raphespinal Neurons in the Neonatal Mouse Brainstem
Spatial Distribution of Serotonergic Raphespinal Neurons in the Neonatal Mouse Brainstem
| dc.contributor.advisor | Perreault, Marie-Claude | |
| dc.contributor.author | Bumgardner, Luke | |
| dc.contributor.committeeMember | Hochman, Shawn | |
| dc.contributor.department | Biomedical Engineering (Joint GT/Emory Department) | |
| dc.date.accessioned | 2019-05-30T16:23:54Z | |
| dc.date.available | 2019-05-30T16:23:54Z | |
| dc.date.created | 2019-05 | |
| dc.date.issued | 2019-05 | |
| dc.date.submitted | May 2019 | |
| dc.date.updated | 2019-05-30T16:23:54Z | |
| dc.description.abstract | Descending serotonergic (5-HT) neurons located in the brainstem are known to influence mammalian locomotion. Neonates have poorer locomotor abilities than adults. Theoretically, a lesser contribution from 5-HT descending neurons in neonates is possible. However, a detailed quantification of 5-HT descending neurons in the neonate has yet to be performed. In this study, we quantify 5-HT descending neurons in each caudal raphe nuclei of the brainstem in the neonatal Pet1-GCaMP6 mouse (P1-P2). Descending 5-HT neurons were present in only three raphe nuclei, the raphe magnus (RMg), the raphe pallidus (RPa), and the raphe obscurus (ROB). Results show that 11% of all 5-HT neurons present in these nuclei project down the brainstem into the spinal cord. The largest majority of 5-HT descending neurons was found in the raphe pallidus (RPa), followed by the raphe magnus (RMg) nuclei, and finally, the raphe obscurus (ROB) nuclei. | |
| dc.description.degree | Undergraduate | |
| dc.format.mimetype | application/pdf | |
| dc.identifier.uri | http://hdl.handle.net/1853/61388 | |
| dc.language.iso | en_US | |
| dc.publisher | Georgia Institute of Technology | |
| dc.subject | Raphe nuclei | |
| dc.subject | Serotonergic neurons | |
| dc.subject | 5-HT | |
| dc.subject | Retrograde labelling | |
| dc.subject | Spinal cord | |
| dc.subject | Control of movement | |
| dc.title | Spatial Distribution of Serotonergic Raphespinal Neurons in the Neonatal Mouse Brainstem | |
| dc.type | Text | |
| dc.type.genre | Undergraduate Thesis | |
| dspace.entity.type | Publication | |
| local.contributor.corporatename | Wallace H. Coulter Department of Biomedical Engineering | |
| local.contributor.corporatename | Undergraduate Research Opportunities Program | |
| local.contributor.corporatename | College of Engineering | |
| local.relation.ispartofseries | Undergraduate Research Option Theses | |
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| relation.isSeriesOfPublication | e1a827bd-cf25-4b83-ba24-70848b7036ac | |
| thesis.degree.level | Undergraduate |