Title:
High-Throughput Screening Identifies Micrornas That Target Nox2 and Improve Function Following Acute Myocardial Infarction

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dc.contributor.author Yang, Junyu
dc.contributor.author Brown, Milton E.
dc.contributor.author Zhang, Hanshuo
dc.contributor.author Martinez, Mario
dc.contributor.author Zhao, Zhihua
dc.contributor.author Bhutani, Srishti
dc.contributor.author Yin, Shenyi
dc.contributor.author Trac, David
dc.contributor.author Xi, Jianzhong Jeff
dc.contributor.author Davis, Michael E.
dc.contributor.corporatename Georgia Institute of Technology. Department of Biomedical Engineering en_US
dc.contributor.corporatename Emory University. Department of Medicine en_US
dc.contributor.corporatename Peking University. Department of Biomedical Engineering en_US
dc.contributor.corporatename Peking University. State Key Laboratory of Natural and Biomimetic Drugs en_US
dc.contributor.corporatename Peking University. State Key Laboratory of Biomembrane and Membrane Biotechnology en_US
dc.date.accessioned 2017-04-07T15:10:12Z
dc.date.available 2017-04-07T15:10:12Z
dc.date.issued 2017-02-24
dc.description Copyright © 2017 by the American Physiological Society. en_US
dc.description DOI: 10.1152/ajpheart.00685.2016
dc.description.abstract Myocardial infarction (MI) is the most common cause of heart failure. Excessive production of reactive oxygen species plays a key role in the pathogenesis of cardiac remodeling after MI. NADPH with Nox2 as the catalytic subunit is a major source of superoxide production and expression is significantly increased in the infarcted myocardium, especially by infiltrating macrophages. While microRNAs (miRNAs) are potent regulators of gene expression, and play an important role in heart disease, there still lacks efficient ways to identify miRNAs that target important pathological genes for treating MI. Thus, the overall objective was to establish a miRNA screening and delivery system for improving heart function after MI using Nox2 as a critical target. en_US
dc.identifier.citation Yang, J., Brown, M.E., Zhang, H., Martinez, M., Zhao, Z., Bhutani, S., Yin, S., Trac, D., Xi, J. J., & Davis, M. E. (2017). High-throughput screening identifies microRNAs that target Nox2 and improve function following acute myocardial infarction. American Journal of Physiology - Heart and Circulatory Physiology. en_US
dc.identifier.doi 10.1152/ajpheart.00685.2016 en_US
dc.identifier.uri http://hdl.handle.net/1853/56610
dc.language.iso en_US en_US
dc.publisher Georgia Institute of Technology en_US
dc.relation.ispartofseries Department of Biomedical Engineering Faculty Publications
dc.subject MicroRNA en_US
dc.subject Myocardial infarction en_US
dc.subject Oxidative stress en_US
dc.title High-Throughput Screening Identifies Micrornas That Target Nox2 and Improve Function Following Acute Myocardial Infarction en_US
dc.title.alternative MicroRNAs Targeting Nox2 en_US
dc.type Text
dc.type.genre Article
dspace.entity.type Publication
local.contributor.author Davis, Michael E.
local.contributor.corporatename Wallace H. Coulter Department of Biomedical Engineering
local.contributor.corporatename College of Engineering
relation.isAuthorOfPublication fab83195-e1b0-4b5e-933d-5b97a14b945a
relation.isOrgUnitOfPublication da59be3c-3d0a-41da-91b9-ebe2ecc83b66
relation.isOrgUnitOfPublication 7c022d60-21d5-497c-b552-95e489a06569
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