Title:
Benign Tunable Solvents for Improved Processing of Pharmaceutically Relevant Products and Catalysts

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dc.contributor.advisor Eckert, Charles A.
dc.contributor.advisor Liotta, Charles L.
dc.contributor.author Hill, Elizabeth M. en_US
dc.contributor.committeeMember Bommarius, Aneas S.
dc.contributor.committeeMember Carson Meredith
dc.contributor.committeeMember Lu, Hang
dc.contributor.department Chemical Engineering en_US
dc.date.accessioned 2007-08-16T17:59:41Z
dc.date.available 2007-08-16T17:59:41Z
dc.date.issued 2007-07-06 en_US
dc.description.abstract Sustainable technologies are vital to reducing the environmental impact of chemical enterprises. Solvents are often seen as just a medium in which a reaction takes place; however they can also play a dominant role in the overall toxicity of a typical pharmaceutical/fine chemicals batch chemical operation. Further, careful solvent selection for a reaction may also lead to more facile separation and purification of products, thus reducing the overall cost of a chemical process. This thesis presents an environmentally benign processing technique for sustainable biocatalytic reactions coupled with facile built-in separation. An organic aqueous tunable solvent (OATS) system allows access to a hydrophobic substrate which is transformed with a homogeneous enzymatic catalyst in a single liquid phase. Subsequent CO2 addition produces a biphasic mixture where the hydrophobic product partitions preferentially into the organic rich phase for separation while the hydrophilic enzyme catalyst partitions into the aqueous rich phase, where it is recyclable. Processing parameters in OATS systems are discussed and an overall product recovery of 80% is observed after six reaction cycles. Additionally, greater than 99% enantiomeric excess (ee) is shown for catalyzed hydrolysis of rac-1-phenylethyl acetate with Candida antarctica lipase B (CAL B) both before and after CO2-induced separation. en_US
dc.description.degree Ph.D. en_US
dc.identifier.uri http://hdl.handle.net/1853/16320
dc.publisher Georgia Institute of Technology en_US
dc.subject Gas-expanded liquids en_US
dc.subject Biphasic separation en_US
dc.subject Biocatalysis en_US
dc.title Benign Tunable Solvents for Improved Processing of Pharmaceutically Relevant Products and Catalysts en_US
dc.type Text
dc.type.genre Dissertation
dspace.entity.type Publication
local.contributor.advisor Eckert, Charles A.
local.contributor.advisor Liotta, Charles L.
local.contributor.corporatename School of Chemical and Biomolecular Engineering
local.contributor.corporatename College of Engineering
relation.isAdvisorOfPublication 4b9f2e38-c211-4513-bc14-84855881983c
relation.isAdvisorOfPublication 70381731-0633-4be9-8756-42fbf84ac767
relation.isOrgUnitOfPublication 6cfa2dc6-c5bf-4f6b-99a2-57105d8f7a6f
relation.isOrgUnitOfPublication 7c022d60-21d5-497c-b552-95e489a06569
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