Title:
Introducing Sustainability into Industrial Homogeneous Catalysis
Introducing Sustainability into Industrial Homogeneous Catalysis
| dc.contributor.advisor | Liotta, Charles L. | |
| dc.contributor.author | Woodham, Wesley H | |
| dc.contributor.committeeMember | Meredith, Carson | |
| dc.contributor.committeeMember | Sievers, Carsten | |
| dc.contributor.committeeMember | Walton, Krista | |
| dc.contributor.committeeMember | Fisk, Jason | |
| dc.contributor.department | Chemical and Biomolecular Engineering | |
| dc.date.accessioned | 2017-01-11T14:00:37Z | |
| dc.date.available | 2017-01-11T14:00:37Z | |
| dc.date.created | 2015-12 | |
| dc.date.issued | 2015-11-13 | |
| dc.date.submitted | December 2015 | |
| dc.date.updated | 2017-01-11T14:00:37Z | |
| dc.description.abstract | This thesis describes four projects focused on the implementation of green chemistry and engineering in an industrial context. The first project describes efforts to transition Meerwein-Ponndorf-Verley reduction technology from a batch-wise production framework to a continuous-flow framework. This work was done in the context of improving the synthesis of HIV-protease inhibitor intermediates. The second project describes a similar transfer of hydropyridoindole synthesis technology from batch processing to continuous-flow processing. In particular, a tandem synthetic pathway was developed for conducting cyclopropanation and ring-opening cyclization reactions in series. The third project describes the development of a novel catalyst separation process incorporating the use of sulfur-containing additives and Organic-Aqueous Tunable Solvents. Specifically, this process is demonstrated on palladium catalysts that have been employed in Suzuki coupling reaction mixtures. The fourth project describes the development of a recyclable catalytic system for use in Suzuki coupling reaction processes. The technology described incorporates the use of water-soluble ligands to generate hydrophilic palladium species that can be recovered via Organic-Aqueous Tunable Solvents and reintroduced as an active catalyst species. | |
| dc.description.degree | Ph.D. | |
| dc.format.mimetype | application/pdf | |
| dc.identifier.uri | http://hdl.handle.net/1853/56216 | |
| dc.language.iso | en_US | |
| dc.publisher | Georgia Institute of Technology | |
| dc.subject | Homogeneous catalysis | |
| dc.subject | continuous-flow | |
| dc.subject | smart solvents | |
| dc.subject | tunable solvents | |
| dc.title | Introducing Sustainability into Industrial Homogeneous Catalysis | |
| dc.type | Text | |
| dc.type.genre | Dissertation | |
| dspace.entity.type | Publication | |
| local.contributor.advisor | Liotta, Charles L. | |
| local.contributor.corporatename | School of Chemical and Biomolecular Engineering | |
| local.contributor.corporatename | College of Engineering | |
| relation.isAdvisorOfPublication | 70381731-0633-4be9-8756-42fbf84ac767 | |
| relation.isOrgUnitOfPublication | 6cfa2dc6-c5bf-4f6b-99a2-57105d8f7a6f | |
| relation.isOrgUnitOfPublication | 7c022d60-21d5-497c-b552-95e489a06569 | |
| thesis.degree.level | Doctoral |