Title:
Chemical manipulation of dental patterning in Malawi cichlids

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dc.contributor.author Bloomquist, Ryan F. en_US
dc.contributor.department Biology en_US
dc.date.accessioned 2008-05-22T17:07:45Z
dc.date.available 2008-05-22T17:07:45Z
dc.date.issued 2008-05-05 en_US
dc.description.abstract A dynamic model for odontogenesis is lacking. Cichlids serve as superior organisms for studies in tooth development because of diversity in tooth shape, size, number, number of rows, all of which undergo continuous replacement, as well as the possession of a second set of toothed jaws, within the posterior pharynx. Through in situ hybridization we have characterized basic patterns of odontogenesis in cichlids that are conserved throughout vertebrates. We have used the teratogens cyclopamine and SU5402 to reduce the function of Shh and Fgf protein, respectively with a time and dose dependence. Cyclopamine trials indicate that Shh is necessary to pattern the dentition and that its expression in the first tooth is essential, as is its interaction with tooth spacing genes in the initiation of a periodic pattern mechanism. Members of the Fgf family are required for proper replacement cycles, possibly through stem cell interactions. en_US
dc.description.advisor Committee Member/Second Reader: Yen, Jeannette; Faculty Mentor: Streelman, Todd en_US
dc.identifier.uri http://hdl.handle.net/1853/21816
dc.publisher Georgia Institute of Technology en_US
dc.subject Cichlid en_US
dc.subject Teeth en_US
dc.subject Tooth en_US
dc.subject Development en_US
dc.subject Cyclopamine en_US
dc.subject SU5402 en_US
dc.subject SHH en_US
dc.subject FGF en_US
dc.title Chemical manipulation of dental patterning in Malawi cichlids en_US
dc.type Text
dc.type.genre Undergraduate Thesis
dspace.entity.type Publication
local.contributor.corporatename College of Sciences
local.contributor.corporatename School of Biological Sciences
local.contributor.corporatename Undergraduate Research Opportunities Program
local.relation.ispartofseries Undergraduate Research Option Theses
relation.isOrgUnitOfPublication 85042be6-2d68-4e07-b384-e1f908fae48a
relation.isOrgUnitOfPublication c8b3bd08-9989-40d3-afe3-e0ad8d5c72b5
relation.isOrgUnitOfPublication 0db885f5-939b-4de1-807b-f2ec73714200
relation.isSeriesOfPublication e1a827bd-cf25-4b83-ba24-70848b7036ac
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