Title:
Mechanistic numerical study of trhombus growth
Mechanistic numerical study of trhombus growth
| dc.contributor.advisor | Ku, David N. | |
| dc.contributor.author | Bark, David Lawrence, Jr. | en_US |
| dc.contributor.committeeMember | Aidun, Cyrus K. | |
| dc.contributor.committeeMember | Giddens, Don P. | |
| dc.contributor.department | Mechanical Engineering | en_US |
| dc.date.accessioned | 2008-06-10T20:36:28Z | |
| dc.date.available | 2008-06-10T20:36:28Z | |
| dc.date.issued | 2007-04-19 | en_US |
| dc.description.abstract | A computational model of thrombus initiation and aggrandizement was proposed. The model separated the thrombotic process into three mechanisms, including shear enhanced diffusivity, platelet margination, and platelet adhesion. The model indicates that transport mechanisms may be the rate limiting condition of thrombus formation at physiological shear rates and that at higher shear rates; platelet binding becomes the rate limiting condition. Additionally a wall shear rate of 20000 s-1 and above should be considered as a new criterion for prophylactic treatment of an atherosclerotic lesion. | en_US |
| dc.description.degree | M.S. | en_US |
| dc.identifier.uri | http://hdl.handle.net/1853/22550 | |
| dc.publisher | Georgia Institute of Technology | en_US |
| dc.subject | Diffusion | en_US |
| dc.subject | Adhesion | en_US |
| dc.subject | Arteriosclerosis | en_US |
| dc.subject | Atherosclerosis | en_US |
| dc.subject | Platelet | en_US |
| dc.subject | Thrombosis | en_US |
| dc.subject | Thrombus | en_US |
| dc.subject | Blood | en_US |
| dc.subject.lcsh | Thrombosis | |
| dc.subject.lcsh | Computational fluid dynamics | |
| dc.subject.lcsh | Blood platelets | |
| dc.subject.lcsh | Transport theory | |
| dc.subject.lcsh | Cell adhesion | |
| dc.subject.lcsh | Shear flow | |
| dc.title | Mechanistic numerical study of trhombus growth | en_US |
| dc.type | Text | |
| dc.type.genre | Thesis | |
| dspace.entity.type | Publication | |
| local.contributor.advisor | Ku, David N. | |
| local.contributor.corporatename | George W. Woodruff School of Mechanical Engineering | |
| local.contributor.corporatename | College of Engineering | |
| relation.isAdvisorOfPublication | fcccb519-e993-4e74-80be-d919b82c6af4 | |
| relation.isOrgUnitOfPublication | c01ff908-c25f-439b-bf10-a074ed886bb7 | |
| relation.isOrgUnitOfPublication | 7c022d60-21d5-497c-b552-95e489a06569 |
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