Title:
The Effect of 3,4-Dihydroxymandelic Acid and Normetanephrine on Amyloid-beta 40 Monomer Aggregation in Alzheimer's Disease Using Molecular Modeling
The Effect of 3,4-Dihydroxymandelic Acid and Normetanephrine on Amyloid-beta 40 Monomer Aggregation in Alzheimer's Disease Using Molecular Modeling
Author(s)
Kim, Joy
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Abstract
Alzheimer’s disease is the one of the most common types of degenerative
dementia. It is known to cause memory loss and loss of other intellectual abilities. The
formation of neurotoxic plaque composed of amyloid beta fibrils has been found in a
relatively high portion of Alzheimer patient’s brains. Investigation into the mechanism of
beta amyloid protein aggregation discovered that the initial amyloid beta monomer
structure misfolds to form oligomers and fibrils as the disease progresses.
3,4 – Dihydroxymandelic acid and normetanephrine are metabolites of
norepinephrine found in the brain. These chemical have been found to have an effect on
fibril formation and aggregation through in vitro experiments. In this study, molecular
dynamic modeling methods will be used to discover the effect of 3,4 –
dihydroxymandelic acid and normetanephrine have on the amyloid beta 40 monomer as
well as try to understand its mechanism.
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Date Issued
2016-07-18
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Text
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Undergraduate Thesis