Title:
Quantification and Analysis of the Geometric Parameters of the Total Cavo Pulmonary Connection Using a Skeletonization Approach

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dc.contributor.advisor Yoganathan, Ajit P.
dc.contributor.author KrishnankuttyRema, Resmi en_US
dc.contributor.committeeMember Oshinski, John
dc.contributor.committeeMember Sharma, Shiva
dc.contributor.department Biomedical Engineering en_US
dc.date.accessioned 2008-02-07T18:14:58Z
dc.date.available 2008-02-07T18:14:58Z
dc.date.issued 2007-08-24 en_US
dc.description.abstract The Fontan repair is a three-stage palliative surgical procedure for single ventricle congenital heart diseases, ultimately resulting in the right heart bypass. This is accomplished by routing the systemic venous return directly to the lungs. Although this procedure reduces the mortality rate, its long-term outcome is still considered far from optimal. Over the years several modifications have been suggested, ultimately leading to the total cavopulmonary connection (TCPC), which is the current procedure of choice. A better understanding of the hemodynamics in the TCPC is critical for further optimization of the TCPC design and surgical planning, which may lead to improved surgical outcome. Recent experimental and numerical studies have focused on characterizing the fluid dynamics of the TCPC but to date no study has attempted to relate the geometry of the TCPC anatomies with their hemodynamic parameters. The present study therefore proposes to quantify the complex geometrical characteristics of patient-specific TCPC anatomies and correlate these characteristics with their hemodynamic efficiency. A technique using skeletonization approach is thus developed to achieve this goal. The centerline approximation of the TCPC geometry is used to extract main geometric parameters such as vessel area, curvature and offset. The developed methodology is then applied to characterize the shape of various TCPC templates including extra-cardiac (EC) and intra-atrial (IA) TCPCs, TCPCs with bilateral Superior Vena Cavae and geometries before the third stage. The obtained geometric parameters are then related to the TCPC hemodynamics, particularly to the power loss. en_US
dc.description.degree M.S. en_US
dc.identifier.uri http://hdl.handle.net/1853/19742
dc.publisher Georgia Institute of Technology en_US
dc.subject Fontan en_US
dc.subject TCPC efficiency en_US
dc.subject Power loss en_US
dc.subject Intra atrial en_US
dc.subject Extra cardiac en_US
dc.subject TCPC en_US
dc.subject.lcsh Congenital heart disease
dc.subject.lcsh Hemodynamics
dc.subject.lcsh Geometry, Descriptive
dc.subject.lcsh Diagnostic imaging
dc.title Quantification and Analysis of the Geometric Parameters of the Total Cavo Pulmonary Connection Using a Skeletonization Approach en_US
dc.type Text
dc.type.genre Thesis
dspace.entity.type Publication
local.contributor.advisor Yoganathan, Ajit P.
local.contributor.corporatename Wallace H. Coulter Department of Biomedical Engineering
local.contributor.corporatename College of Engineering
relation.isAdvisorOfPublication 6a910742-4bed-4ba6-b03d-f92e4c915a00
relation.isOrgUnitOfPublication da59be3c-3d0a-41da-91b9-ebe2ecc83b66
relation.isOrgUnitOfPublication 7c022d60-21d5-497c-b552-95e489a06569
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