Title:
Custom design of the cardiac microenvironment with biomaterials

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dc.contributor.author Davis, Michael E. en_US
dc.contributor.author Hsieh, Patrick C.H. en_US
dc.contributor.author Grodzinsky, Alan J. en_US
dc.contributor.author Lee, Richard T. en_US
dc.contributor.corporatename Harvard Medical School en_US
dc.contributor.corporatename Brigham and Women’s Hospital. Cardiovascular Division en_US
dc.date.accessioned 2013-06-03T20:16:35Z
dc.date.available 2013-06-03T20:16:35Z
dc.date.issued 2005-07
dc.description © 2005 American Heart Association, Inc. All rights reserved. The electronic version of this article is the complete one and can be found online at: http://circres.ahajournals.org/content/97/1/8 en_US
dc.description DOI: 10.1161/01.RES.0000184694.03262.6d en_US
dc.description.abstract Many strategies for repairing injured myocardium are under active investigation, with some early encouraging results. These strategies include cell therapies, despite little evidence of long-term survival of exogenous cells, and gene or protein therapies, often with incomplete control of locally-delivered dose of the factor. We propose that, ultimately, successful repair and regeneration strategies will require quantitative control of the myocardial microenvironment. This precision control can be engineered through designed biomaterials that provide quantitative adhesion, growth, or migration signals. Quantitative timed release of factors can be regulated by chemical design to direct cellular differentiation pathways such as angiogenesis and vascular maturation. Smart biomaterials respond to the local environment, such as protease activity or mechanical forces, with controlled release or activation. Most of these new biomaterials provide much greater flexibility for regenerating tissues ex vivo, but emerging technologies like self-assembling nanofibers can now establish intramyocardial cellular microenvironments by injection. This may allow percutaneous cardiac regeneration and repair approaches, or injectable-tissue engineering. Finally, materials can be made to multifunction by providing sequential signals with custom design of differential release kinetics for individual factors. Thus, new rationally-designed biomaterials no longer simply coexist with tissues, but can provide precision bioactive control of the microenvironment that may be required for cardiac regeneration and repair. en_US
dc.identifier.citation Davis M.E., Hsieh P.C.H., Grodzinsky A.J. and Lee R.T., “Custom design of the cardiac microenvironment with biomaterials,” Circulation Research, 97, 1, 8-15 (July 8, 2005) en_US
dc.identifier.doi 10.1161/01.RES.0000173376.39447.01
dc.identifier.issn 0009-7330
dc.identifier.uri http://hdl.handle.net/1853/47158
dc.language.iso en_US en_US
dc.publisher Georgia Institute of Technology en_US
dc.publisher.original American Heart Association en_US
dc.subject Tissue engineering en_US
dc.subject Biomaterials en_US
dc.subject Regeneration en_US
dc.subject Microenvironment en_US
dc.title Custom design of the cardiac microenvironment with biomaterials en_US
dc.type Text
dc.type.genre Article
dspace.entity.type Publication
local.contributor.author Davis, Michael E.
local.contributor.corporatename Wallace H. Coulter Department of Biomedical Engineering
local.contributor.corporatename College of Engineering
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relation.isOrgUnitOfPublication da59be3c-3d0a-41da-91b9-ebe2ecc83b66
relation.isOrgUnitOfPublication 7c022d60-21d5-497c-b552-95e489a06569
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