Platelet Adhesion and Mechanosensing on Collagen Coated Substrates

dc.contributor.author Kee, Matthew
dc.contributor.committeeMember Lam, Wilbur
dc.contributor.committeeMember Barker, Thomas
dc.contributor.committeeMember Behravesh, Esfandiar
dc.contributor.department Biomedical Engineering (Joint GT/Emory Department)
dc.date.accessioned 2015-08-18T19:15:04Z
dc.date.available 2015-08-18T19:15:04Z
dc.date.created 2015-05
dc.date.issued 2015-08-18
dc.date.submitted May 2015
dc.date.updated 2015-08-18T19:15:04Z
dc.description.abstract Platelets play a critical role in maintaining homeostasis of the body. In order to protect the body from significant injury, platelets adhere to the vascular wall preventing critical vascular system failure. When the collagen is exposed on damaged endothelial cells, platelets adhere to the exposed protein and spread, increasing the size of the clot and preventing further damage to the body. For hemostatic diseases, biomechanical properties of platelets are an area of research critical to helping understand arterial diseases while also furthering the treatment of them. Platelet clot formation relies on the biomechanical aspects of the platelet surroundings as they adhere to the cell wall. It is hypothesized that an increase in the substrate stiffness on which platelets adhere to will increase the spreading area of the platelet in both static and dynamic environments. This paper shows a novel approach to better comprehend biomechanical properties of platelets relating to adhesion and spreading on varying substrate stiffness of collagen-coated polyacrylamide gels.
dc.description.degree Undergraduate
dc.format.mimetype application/pdf
dc.identifier.uri http://hdl.handle.net/1853/53743
dc.language.iso en_US
dc.publisher Georgia Institute of Technology
dc.subject Platelets
dc.subject Thrombosis
dc.subject Collagen
dc.title Platelet Adhesion and Mechanosensing on Collagen Coated Substrates
dc.type Text
dc.type.genre Undergraduate Thesis
dspace.entity.type Publication
local.contributor.corporatename Wallace H. Coulter Department of Biomedical Engineering
local.contributor.corporatename Undergraduate Research Opportunities Program
local.contributor.corporatename College of Engineering
local.relation.ispartofseries Undergraduate Research Option Theses
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relation.isOrgUnitOfPublication 0db885f5-939b-4de1-807b-f2ec73714200
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thesis.degree.level Undergraduate
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