Title:
Development of poly(3-octylthiophene) thin films for regulating osteoblast growth

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dc.contributor.advisor Meredith, J. Carson
dc.contributor.author Rincón-Rosenbaum, Charlene en_US
dc.contributor.committeeMember Lu, Hang
dc.contributor.committeeMember Joseph Schork
dc.contributor.committeeMember William Koros
dc.contributor.committeeMember Yadong Wang
dc.contributor.department Chemical Engineering en_US
dc.date.accessioned 2009-01-22T15:40:19Z
dc.date.available 2009-01-22T15:40:19Z
dc.date.issued 2008-08-25 en_US
dc.description.abstract The overall objective of this work was to assess the suitability of poly(3-octylthiophene) (P3OT) to sustain MC3T3-E1 osteoblast attachment and growth. The central hypothesis was that specific P3OT film properties (i.e., thickness, film preparation conditions, and level of doping) are able to regulate osteoblast functions (i.e., attachment and proliferation). Discrete and combinatorial techniques were utilized to prepare and characterize thin films of P3OT, a semiconductor in its undoped state, and to study its interaction with MC3T3-E1 osteoblasts. In this work we demonstrate that P3OT is a suitable surface to sustain MC3T3-E1 attachment and proliferation with no observed cytotoxicity. We show that P3OT has an effect on MC3T3-E1 attachment and proliferation as area, circularity, and proliferation ratio are significantly different for P3OT compared to control surfaces. We also demonstrate that P3OT doping and film preparation conditions have an effect on osteoblast attachment and proliferation but that thickness over a low and high range does not affect osteoblast functions. This work is significant because it contributes to the growing area of conducting polymers in biomedical applications and establishes P3OT as a potential cell substrate that sustains MC3T3-E1 attachment and promotes high levels of cell proliferation. en_US
dc.description.degree Ph.D. en_US
dc.identifier.uri http://hdl.handle.net/1853/26493
dc.publisher Georgia Institute of Technology en_US
dc.subject Cell proliferation en_US
dc.subject Cell attachment en_US
dc.subject Poly(3-octylthiophene) en_US
dc.subject Conducting polymers en_US
dc.subject MC3T3-E1 osteoblasts en_US
dc.subject.lcsh Thiophenes
dc.subject.lcsh Thin films
dc.subject.lcsh Conducting polymers
dc.subject.lcsh Biomedical materials
dc.title Development of poly(3-octylthiophene) thin films for regulating osteoblast growth en_US
dc.type Text
dc.type.genre Dissertation
dspace.entity.type Publication
local.contributor.advisor Meredith, J. Carson
local.contributor.corporatename School of Chemical and Biomolecular Engineering
local.contributor.corporatename College of Engineering
relation.isAdvisorOfPublication b7e217bc-d8fe-480b-8b55-5c2571986a3a
relation.isOrgUnitOfPublication 6cfa2dc6-c5bf-4f6b-99a2-57105d8f7a6f
relation.isOrgUnitOfPublication 7c022d60-21d5-497c-b552-95e489a06569
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