Multi-scale computational modeling of particle adhesion dynamics under shear flow

dc.contributor.advisor Aidun, Cyrus K.
dc.contributor.author Zhu, Yuanzheng
dc.contributor.committeeMember Ku, David
dc.contributor.committeeMember Smith, Marc
dc.contributor.committeeMember Vuduc, Richard
dc.contributor.committeeMember Lam, Wilbur
dc.contributor.department Mechanical Engineering
dc.date.accessioned 2020-09-08T12:43:18Z
dc.date.available 2020-09-08T12:43:18Z
dc.date.created 2019-08
dc.date.issued 2019-07-30
dc.date.submitted August 2019
dc.date.updated 2020-09-08T12:43:18Z
dc.description.abstract Challenging questions exist in the understanding of particulate adhesion process in biological and industrial flows since these problems require modeling a wide range of spatiotemporal scales. The thesis is focused on multiscale modeling of particle adhesion process in shear flow with broad applications to practical suspension flow problems. The capabilities of this model were demonstrated by application to two different problems. In the application of thrombus simulation, a physical description of the von Willebrand factor (VWF) mediated thrombus growth process was formulated. The physics-based model captures distinct stages of the thrombus growth process in shear-induced platelet adhesion (SIPA) and platelet-aggregate morphology. It describes platelets dynamics, VWF dynamics, shear-dependent VWF domain activation, and VWF-platelet binding interactions under complex flow conditions. The model is useful in studying blood diseases like thrombotic microangiopathies (TMAs). By modeling interactions between VWF and platelets under physiological shear conditions, a stable web-like scaffold was formed, resulting in a complex network of cross-linked VWF and platelets that may contribute to microvascular obstruction. The results provide additional biophysical insight into the pathophysiology of TMAs. Another application is crystal formation and adhesion to surfaces in shear flow. A similar particle adhesion model framework was applied to study the scale induction when crystal fouling begins. Crystals adhere faster at lower wall shear rate and lower viscosity conditions. Also, crystals tend to form on top of the existing nucleus, forming 3D structures as compared to uniform adhesion on smooth surfaces.
dc.description.degree Ph.D.
dc.format.mimetype application/pdf
dc.identifier.uri http://hdl.handle.net/1853/63565
dc.language.iso en_US
dc.publisher Georgia Institute of Technology
dc.subject Particle adhesion dynamics
dc.subject Computational fluid dynamics
dc.subject Thrombosis
dc.subject Numerical methods
dc.subject Blood flow
dc.subject Computational biology
dc.subject Multi-scale modeling
dc.title Multi-scale computational modeling of particle adhesion dynamics under shear flow
dc.type Text
dc.type.genre Dissertation
dspace.entity.type Publication
local.contributor.advisor Aidun, Cyrus K.
local.contributor.corporatename George W. Woodruff School of Mechanical Engineering
local.contributor.corporatename College of Engineering
relation.isAdvisorOfPublication 4b7dc133-2272-48c8-90bc-5f8401a4222c
relation.isOrgUnitOfPublication c01ff908-c25f-439b-bf10-a074ed886bb7
relation.isOrgUnitOfPublication 7c022d60-21d5-497c-b552-95e489a06569
thesis.degree.level Doctoral
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