Title:
Aptamer-Guided Gene Targeting

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dc.contributor.patentcreator Storici, Francesca
dc.contributor.patentcreator Ruff, Patrick
dc.date.accessioned 2021-11-12T17:16:46Z
dc.date.available 2021-11-12T17:16:46Z
dc.date.filed 7/17/2015
dc.date.issued 4/17/2018
dc.description.abstract Compositions and methods for modifying genetic material are provided. One embodiment provides aptamers capable of binding to a site-specific DNA binding moiety to facilitate the exchange of homologous genetic information between a donor molecule and the desired target locus (aptamer-guided gene targeting or AGT). One embodiment provides an oligonucleotide containing a aptamer, preferably a DNA aptamer at the 5′ end. The oligonucleotide also contains a region of homology, also referred to as donor DNA, to a desired nucleic acid, locus, or gene. The DNA binding moiety can be a nucleic acid, a protein, or a complex of proteins. In a preferred embodiment the DNA binding moiety is a homing endonuclease that cuts DNA to facilitate the modification of the DNA by the donor DNA.
dc.description.assignee Georgia Tech Research Corporation
dc.identifier.cpc C12N 15/115
dc.identifier.cpc A61K 31/7088
dc.identifier.cpc A61K 31/711
dc.identifier.patentapplicationnumber 14/802,832
dc.identifier.patentnumber 9944933
dc.identifier.uri http://hdl.handle.net/1853/65444
dc.title Aptamer-Guided Gene Targeting
dspace.entity.type Publication
local.contributor.corporatename Georgia Institute of Technology
local.relation.ispartofseries Georgia Tech Patents
relation.isOrgUnitOfPublication cc30e153-7a64-4ae2-9b1d-5436686785e3
relation.isSeriesOfPublication 0f49c79d-4efb-4bd9-b060-5c7f9191b9da
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