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Bioengineering Seminar Series

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https://hdl.handle.net/1853/70845
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2001 - 2009 21
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Publication Search Results

Now showing 1 - 10 of 21
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    Design Principles for Cytokine-Neutralizing Polymers
    (Georgia Institute of Technology, 2009-11-19) Washburn, Newell R.
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    Smart Biomaterials Inspired by Nature's Mechanisms
    (Georgia Institute of Technology, 2009-10-29) Murphy, William L.
    Control over the soluble signals that cells encounter in their local environment is a common theme in natural tissue formation, and also an emerging theme in functional tissue engineering strategies. This concept is particularly important in stem cell-based applications, in which local soluble signals can dictate cell fate decisions. Therefore, there is significant interest in using bioengineering approaches to control soluble signaling in the stem cell microenvironment. Nature often achieves intricate control over local soluble signaling via specific, non-covalent interactions. Inspired by these natural interactions, we are interested in creating biomaterials that actively regulate soluble signaling. For example, our recent studies have used engineered protein-peptide and protein-mineral interactions to build new classes of materials that are bio-responsive and capable of regulating growth factor signaling. This talk will specifically highlight bio-inspired protein conformational shifts and engineered growth factor sequestering as mechanisms to regulate stem cell behavior upon and within biomaterials.
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    EGFR Family Gymnastics
    (Georgia Institute of Technology, 2009-10-22) Griffith, Linda G.
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    Scalable Manufacture of Cells
    (Georgia Institute of Technology, 2009-09-10) Rao, Mahendra S.
    Preparing cells for therapy requires developing a scalable GMP'able model for cell culture for the undifferentiated cells and for the differentiated cells derived from them. It is also important to develop testing processes and process for freezing and thawing and selection. Using dopaminergic neuron differentiation as an example I will discuss developing a protocol for obtaining dopaminergic neurons suitable for therapy or for screening.
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    Tissue Engineering and Regenerative Medicine: A Surgeon’s Perspective
    (Georgia Institute of Technology, 2005-04-08) Vacanti, Joseph P.
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    Professional Opportunities in the Pharmaceutical Industry in the 21st Century
    (Georgia Institute of Technology, 2004-10-29) Wasserman, Martin A.
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    Mechanisms of Embryonic Stem Cell Self-Renewal
    (Georgia Institute of Technology, 2004-10-26) Dalton, Steve
    Embryonic stem (ES) cells have the capacity for unlimited proliferation and differentiation into a wide range of cell types. Our long-term goals are to define the molecular mechanisms underpinning self-renewal and pluripotency of murine ES cells with the expectation that this information will; (i) define fundamental mechanisms of early embryonic development and, (ii) generate enabling technology that will give utility to ES cells in the area of regenerative medicine. This talk will focus on the molecular mechanisms underpinning self-renewal mechanisms of ES cells and will consider the similarities between stem cells and tumor cells.
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    A Biological Engineered Approach to Enabling Adult Stem Cell-Based Biomedicine
    (Georgia Institute of Technology, 2004-09-21) Sherley, James
    Adult stem cells (ASCs) have potential application in several areas of biomedicine, including cell therapy, gene therapy, and tissue engineering. However, development of ASCs for this purpose has been precluded by difficulty producing them in sufficient number and, consequently, limited knowledge of their properties. We developed a biological engineered approach for ASC production that is based on suppression of asymmetric cell kinetics (SACK). The SACK method effectively expands ASCs from diverse mammalian tissues. Investigations with the expanded ASCs confirmed that ASCs exhibit adifferentiation under conditions that induce active differentiation of their progeny cells. ASC adifferentiation may be the key to discovery of markers that uniquely identify ASCs, another critical tool needed to enable ASC-based biomedicine.
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    Single molecule studies of membrane structure in live cells
    (Georgia Institute of Technology, 2004-02-19) Ritchie, Ken
    Interactions between a cell and its environment must be transmitted through its plasma membrane. As such, the membrane must have mechanisms to control the localization and interactions of its constituent proteins. I will discuss single molecule tracking (at observation rates up 40500 Hz) and scanning optical force microscopy studies of integral membrane proteins and lipids in the plasma membrane of live cells. It is found that the membrane-associated actin cytoskeleton adds the ability to control the diffusion of molecules in the two-dimensional fluid membrane. The consequences of this for cellular signaling will be discussed.
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    Protein Surface Interactions: Role in Biocompatibility
    (Georgia Institute of Technology, 2004-01-22) Brash, John L.