(Georgia Institute of Technology, 2021-05)
Bryant, Graham G.
This research project employs an untargeted approach using RNA sequencing to identify miRNA in saliva following a traumatic brain injury, specifically a concussion, to better understand how acute brain injuries can be diagnosed and treated. There is currently no biological test in place for diagnosing concussions, which are one of the most frequently observed sport related injuries. This study is invested in determining novel molecular biomarkers in saliva that are associated with concussion so that they can then be correlated with symptoms of concussion. The study predicted that salivary miRNA levels are altered in children with concussion, and there will be a significant difference in levels of miRNA at baseline (pre-injury) and post-injury in athletes. By determining novel biomarkers, noninvasive saliva testing may help to better identify concussions and prevent premature return to play as well as a better understanding of injury mechanisms.