Next up will be Abigail Paulson speaking on her work on "Rhythms to the Rescue: Sensory Flicker as a Potential Therapeutic for Alzheimer's disease". Alzheimer's disease is a devastating neurodegenerative disorder. And unfortunately, Alzheimer's is so prevalent, it's likely to affect many of us in some way. Maybe you have a parent or grandparent who's experienced the progressive memory loss and eventual loss of independence that's common to all timers. But even before the first signs of memory loss, there are changes happening at many levels inside the brain. One of these changes is the accumulation of toxic proteins which damage the function of cells in the brain. Because of these early changes, toxic proteins have been a popular target for potential drugs to treat Alzheimer's. However, despite decades of research, the failure rate of current therapeutics in clinical trials is almost 98%. Because of these failures. My thesis project proposes that we look at all timers and a new way. I'm proposing an innovative brain stimulation technique that targets the brain, not at the scale of protein changes, but at the level of brain rhythms. Rhythmic activity in the brain is important for healthy brain function. When you listen to music, you understand just how important rhythms are. If the tempo of one instrument is off, the song no longer makes sense. And it's really similar in the brain. We know that there are some brain rhythms that are essential for memory. And in Alzheimer's disease, these rhythms are altered. We found that we can target this rhythmic neuroactivity using a stimulation approach that we call Flickr. Flickr consists of sounds or lights and sound turning on and off very quickly at 40 times a second. When we in our collaborators exposed a mouse model of Alzheimer's disease to Flickr, we found three exciting things. First, we found that we can stimulate the brain using Flickr, not just in areas of the brain that typically respond to light and sound, but also in areas of the brain that are important for memory. Second, we found that prolonged exposure to Flickr actually reduces the levels of toxic proteins that accumulate during Alzheimer's disease. And third, we found that exposure to audio Flickr actually improves cognition, improves types of memory called spatial and recognition memory. I'm really excited about these findings because they show that we can use Flickr, a non-invasive, non-pharmaceutical technique to not only impact the effects of Alzheimer's disease inside of the brain, but also to improve brain function. Already, Flickr is in human clinical trials. And I hope it will continue to develop into a therapeutic technique that will improve the lives of patients with Alzheimer's. Thank you.