I'm Devon Brown on staff here at I.E. and and be introducing our speaker today substituting for David got feet who is traveling to Seattle for the the N.C.I. annual meeting that's being held at University of Washington. So our next nanotech will be two weeks from today and that talk will be Surendra Czaban from Capsis and that talk will be on current and future cell therapies for treatment of type one diabetes so that's the next nanotech That's coming up. But today I have the pleasure of introducing Dr Michael Veron Burke who is assistant professor here in mechanical engineering at Georgia Tech. Prior to. Georgia Tech he was assistant professor. Technion Israel Institute of Technology and also he has held the position as a researcher in evolutionary biomaterials at Max Planck Institute for metals research so today he has a really interesting talk and the title is a biologics and try to biology He says even fictional address of the last Eric is a lost American surfaces so please. Welcome Dr Varian. OK to everyone so. Few years of evolution have led to a. Biological systems that can so as a source of inspiration. Really. Which is the science of technology for the rocking services so. We can. It is possible to look at the surfaces that are found in the different attachments rock shows in malls and we can there are the NIEs there are several structures that can be associated with two main groups the group one is shown here that is associated with a smooth surface that there are. Occasional. Three frog. If you find something like these so. Certain structures that help us to grasp things well so one group is a small service as there is also in the other group that is based on the higher e micro structures that are shown. In the these slides and these services process heris that terminate at the with field feel the theme field throughout China so for different. Sizes and examples that you see here are for being told fly spider there and. So we can learn a lot from this structure is the question is how and in principle or thinking about the questions that need to be answered that when working with this surface is first of all we should think about what are the mechanisms that he them that he will behind the effective performance of these structures and whether it is possible to abstract these structures and to build something similar based on the simple engineering engineering materials to use it for technical applications. You don't have to answer these questions we need to know how to model biological surfaces using engineering materials and also how to test them at the cuartel. In order to measure a force that the generated in in between surfaces first of all I would like to talk about. These more simple questions and then I will give you several examples of what we did in this direction in finding how to mimic the surfaces and what they can be used for. So in order to more though biological or surfaces we lost the merits which able to recover from large deformations and also able to dissipate McCain just so the result of. Good correspondence between biological very complex structures and simple textures that can be made from from. From official materials to materials that we usually use Pedia mass wanted me to look sun which is a. Rubber like material that cross links with several of the temperature that is a little bit higher than the room temperature and one of the new still works on that which is also rather like material that is used by. Dental walks to court be what it will have in our offices in order to make prostate sick. And this material a problem arises within really really short time five minute that the room temperature now that we used to build this structure is some based on the soft for the lethal graffiti which is a raging. For the resists layer on top of silicone the way for and then the pouring. Busy a mess for instance that cross links in contact with this template and then it can be peeled and the used for different experiments and the way also uses a metal greeds prepared on the thin sheet metal that is. That is. That. There's a certain greeds that are created by lasers that have through opening and then they again we can use. That that sort of if I really slow. Relatively fast and then before they get to the other side of this metal greed they the. Only fight we can then feel them off and they use it in different experiments now their operatives that would be able to test this structure is a strong schematically here so it consists of two main units you need number one is use the four for displacement so it is consists of three stages and on these three stages we fix mating call interface which is. Usually made from. Material that has one the rod the rigidity of freedom which holds to adjust to so for a lot when it comes to contact with its counter face the other same ball that is. Cast from either of the two mirrors that the walk with it is fixed to a measuring lever that consists of to. Force sensors that help us to measure a normal force so when the mating surfaces brought on contact with the same pole a normal force gauge is law that in that we can control the normal log when the same pull these drugs are a little to the contact plane we can measure friction of forces by. The lising deflection of the sensor This device is. To be very small it and it can be feet into the Vulcan chambre of electron of scanning electron microscope because it is good to measure forces that are generated by different structures but the way also needed to see what this force is due to. New structures that would be and this is one of the recent examples of the surface texture that is a law that in the normal direction when this force when this. Up our offices assembled outside they Sam we can place it under the optic microscope in order to see through all that there on spot on. Through the spot on the substrate what is the real current that air and how it evolves in response to different forces that we apply to structures which is extremely important in trying to understand how with their weights now this is. A fourth of the device these. Yellow. Dangles represent four sensors that help us to measure forces junior rated here at the interface between two same balls that are not really well seated and they saw this stages that help to move one of the same balls and all through their actions the device is assembled. On the cover of the C.M. and this is the into which it can be it can be pushed and to be operated inside so just part of my talk will consist of discussing how we can. Feel feel feel feel gentlemen also on the ends of these Harris and what we can learn from them. So looking at these staying in Harris that are found in different animals that they evolved independently we can see astonishingly similar Jorma do when we compare them. To give it so this film films found on the attachment of hair as in the beetle fly spider and the get go and you can see that they all look very similar they all rate like. Things feel. And you can think about duct tape that you peel to your touch tool to table for instance and if you pull it in different directions it will respond differently so this is their idea that is employed in. These structures it is possible to explain it based on candle model that is committed to going to hear of so if this is the duct tape that I just mentioned the force that you need to apply you know that from the surface will depend on three part I mean there is one on that angle if you peel it if you try to pull it in the direction of the film it will hold well if you will peel it in opposite direction. Detach very easy to do so angle is important the second parameter is of course chemistry of the interface and it also depends on the weaves of these Feel so the contact area is not really important what is important is the wave of this field that their minds the force and these laws to use their variable surface area in the much more efficient way if we split the large quantity into a large number of small films and then the force that we need to our plane order to detach the whole structure from the surface will a proportional to the top hole we have two of the total length of all with some together so this is their idea and we want to test it in or at least to verify that. These. Is correct based on measurements of real Any most and. Results that they represent total feeling like line length the sum of fall silent sum of all contact elements. In about twenty different animals to represent it as a function of their body mass you can see here that boys you must ranges within the more than four of those are from are going to hew wood from server roll micrograms from my it's to over one hundred grams for get core and total peeling a line ranges within eight orders of magnitude from several micrometeorites for my it's to over one kilometer for get caught and clearly you can see that there exists a good correlation between these two parameters so we wanted to. Employ these Sadia and we had to find their way how to create this structure as with this field base. Texture that will enable us to test whether it will walk in artificial surfaces so technical solutions to overcome several problems which are increasing the peeling the line length without walking away with a large number of these projections which is not very easy to make them so we we solve it by suggesting working with the longer wall shaped structures. Ease of template. Through release we achieve this by working with projections that roughly pippins equal to this office and we also had to secure gradients and projection with which is brought parity that is associated with. Harris that are found in different emails so the solution schematic a presentation of the solution can be seen here so will shape the projections that. It's a deep thought and has a flexible clips that can do for easily when they come in contact with the. Interface So we found. When you. When you that it was able to create any. Openings within. This two examples hall inside the hall and through floor within the blind range and this is an example of one of the fields through aisles of. The projection of the surface truck sure that they were created based on this principle. Now also for. Micro structures that were created recently so this is what we have now and example of image of banks than templates that. It is laser machined to have structureless that they use there's a template in curing the this is an image of the projections that were created from even use look some cost against this template and this is Sam images of. Projections having different heights and this is a short video that. Represents how they structure is operate when they logged it in normal and then in. Direction to OP was a sight so we can see how these structures can invert themselves and. Themselves brought purely to. Their face so you know that to test their operation we. Focused on. Verifying that they are that pulling angle is indeed important but I meter so we design the test in the which the surfaces swore Lord that normally these. Way until a certain a very light load was achieved and then the way I applied the. Displacement to. A lie in the oldest structure is in the same direction this is the result of force measurement friction force are present at the displacement. Bleck lie in the represents through force and great ally in the. Normal force so when the displacement is applied the surfaces initiated you for an elastic and then they start to slide this is the point of slide you conception this is the point where surfaces of a so on and aligned together now. Actually we wanted to test the pool of forests when they surface as started to be started to be withdrawn from each other in different points and this is a schematic representation so after a certain displacement is applied we start pulling our counter for different angles and measure of the forces that the junior weight at this moment so in the represents the force of the generated at the time of the pulling and the gray line represents the normal component saw the lowest point of actually gives us the pull of force the force needed to be generated in order to detach surfaces from each other and these are this is the summary of all the tests that we that we made to study pulling angle they fit the bullying deliberately made displacement so color of here represents normal force and it can be clearly seen that there is an optimal for the pulling angle and for the preliminary displacement which. Suggests or proves that indeed the surfaces can be used. In. In adjustable way saw the pull force can be efficiently changed when pulling the service a different directions when angles are large detaches with zero force with when angles ranges within. Seventy two one hundred degrees then the force. For the generated achieves Mark Simone. Very was and also found that. The best results are achieved when preliminary displacement. Equal to half the distance needed to start sliding so some way here which can be explained in the following way when the preliminary displacement is not large enough then all these projections are not aligned well and they do not perform more efficiently when. Really near displacement is very higher than sliding starts which means that each of the structure starts sliding. And sliding and they all stressed to a different extent which again the results in the not uniform not if you should performance however somewhere in between there is an optimum range when the force is. In other topic that we started with this structure as was the effect of contact splitting it is accepted to think that splitting a large quantity into smaller structures. To withstand. Detrimental effects associated with increasing in the roughness So we wanted to test the correlation between contact splitting and roughness of the substrate so we prepared actually we use the same. Micro structures and cut them with. Blades. To have. Longer Wallsten to much shorter sections and we tested them against twelve or so different substrates having various. Roughness what you see here is the same images of. A projection some contact with. With different substrates and this is the result so we can indeed to see that when we have a small sort of force then pool of force is not affected by a by contacts breeding saw longer walls of pureed the same way as they say is the walls cut in short the sections but when the roughness starts increasing we can clearly see that poor force drops quite fast and when we have a structure that splits into sections then this police service is able to do with distended or mental effects associated with roughness too much more in a much more efficient way you know what you see here is the result of measurement of friction against several rough substrates first of all we can see that increasing the roughness results since you can reason for action forces which is expected and we can also see that friction or force as measured with structure with microstructure is extremely high with a ratio of friction to normal log of over one hundred you can see it here for Lords of two or three meter you don't get friction force of about five hundred million units which is very. Efficient. And larger friction forces that may find that. In different fields. And this is just one example of possible. Beacon drop process is associated with for instance handling the way for in. Semiconductor industry usually it is made based. On. Suction the vacuum systems that require sealing and quite. Installation of the system so using. Get call like micro structures can make it probably much more efficient but this is a question of future so far we didn't have. We didn't have a new collaboration in this respect. The second example that I would like to. RIP to present here eases. Is related to working with this move a small first structures especially with. Textures found in. Three forms. Looking at this three A most you can clear recognize that they belong to a totally different group that there is not much common in between However if you look at their contact forces we find great similarity between them all of all of all of this. Excitement only shape shaped projections that evolved in the response to interaction between. Tall and the substrate so the question that we head to ask ourselves fellows was what was the reason that led to appearance of similar structures in different animals and thinking about the. Conditions in which. This structure of operate we can see two different things one. The same oath can seek to very sick certain examples of a hand surfaces and the second all three of them killed can jump so high friction forces result and given that all. This textures process some lubrication layer it is important that clearly. Is known to reduce friction so we had to find out whether the structure of these structures evolved in order to do to fight friction oriented problems or. To improve. Attachment So the. What is this was that this texture is a lesion or ranted and the explanation for this is surely here there is a contact splitting principle that defined the round jelly years ago so that saying that if if we sprayed large conduct into small sub contacts if the contact area remains the same but number of contact increases it should it should lead to higher or the Asian force and the second report this is was that the texture is fictional rendered which is associated to the presence of lubrication layer even if you think what can happen the with. Surface grip when when surfaces that come in contact are separated by a lubricant play or you can look at this car that. Hydroplaning loses direction with with the road so probably these channels that are found in between the exceptional projections are needed in order to drain the contacts to remove liquids out of the. Office. So in order to test both people there is this one we had to Kuwait just to break this structures and this is schematic a presentation of HICKS I've got gnarly shaped projections that we cross from different materials who walked with the Bolivian work song and be G.M.'s this is schematic with three part of me that was that important high and size. And this is a C.M. that. Structures and it would cost the same to have a different. Aspect ratios or density as Heights and. Sizes Beirut so we arranged all our meters in order to see how. They operate so first of all we that we tested their attachment ability in order to verify these contacts bleeding principle and it appears that that is wrong so. What you see here are poor forces represented as a function of the number of contacts when we have more. On the surface while the contact area was the same in both cases this is lubricated conduct this is the right contact you can clearly see that despite the number of surface projections increases by about two orders of magnitude we have the same pool of forces in both the right and the brigade contact which means that the contacts bleeding broad principle doesn't work here so all we turned our attention to frequently they just send with us that the structures in both lubricate it the right conditions so this is the result of friction force as measured in texture than textured surfaces in labor. That conditions of. More or less identical or similar to real world application so we can clearly see that the surface that was not textured and we always use some reference. Surfaces that didn't have these projections so not textured surfaces has shown very a lot of frictional force while textured surfaces clearly demonstrate that as the structured surface slides against the surface against the substrate friction force starts to increase and we can see the same. Images of the frog that jumped on the on the three If we zoom in the region of. The interface between the door and the three we can see the race of initial sliding which means in Usually there is a lot of lubricant that the interface during the sliding it is it is squeezed out until the is able to get a good grasp and sit on the surface. We were really surprised to see very interesting results in seeing dry slicing condition so what do you see here or is the performance of. Smooth surface sliding against. The substrate and we can clearly observe days here sticks leap. Motion which. Can be explained in the following way when we have a rigid surface that slides against their last summer which cannot really slide in an accepted way the surface even behind the contact is intention on the surface and front of the contact is in compression so with buckles and then a small wave is created in front of the rounds. In the between two surfaces. Relaxation and surface actually moves not as a result of sliding but as a result of the displacement that the interface so this is how smooth surface the rates and surprisingly textured surface. This same post with. Appearance sliding. In this move to wait another two weeks play in this behavior we would create we develop this story more dull that in the very simple way to explain that the reason is that you stick. Violence in in broad purchase of the services that come and go and so what you see here is. Boise That is. Placed on the moving there and this muscle is the block is connected with spring to the wall then the three parameters that we change here. Springs to from this. And kinetic sick freak. Interface So when when the conveyor starts moving then the block actually sits on the surface that you just touch it fiction movies together with the block and this bring is loaded when the elastics rests when the last tick force. Achieves a certain. Value it becomes larger than this starts it Friesian and the block moves back until. Kinetic friction is achieved and then the process is repeated again so. This was this were unusual conditions and we started to believe this block into a large amount of small. Of small rocks while the total Stephen the sun forces in some remained the same so the interesting thing when there was pretty large surface and to too small a surface if. There is. An and this in both borders. If the properties have the same. Values then they actually friction force behaves saluted the same way however if we enjoyed use some statistical environs and all three properties then difference of starts to be seen friction force shown as a function of displacement appears to have some fluctuations that resemble. More natural behavior of the surface that come in contact and so this is what is what is what was up there in for just two elements if we increase the number of elements then these are the results obtained for fifty small blogs or five thousand clearly this lighting. Becomes much more smoothly and we do not see this like. Soul doth like behavior do you see moving or first last and most and the interesting thing is that when Green is. Very then actually friction force has to be similar to the result that we see in the. Bravest slide the so. Very simple model doing more though allows us to explain the differences between surfaces that process different number of elements if this elements have some variance in their properties so we were also interested to see they affect different geometry by meters and I mean that we walk with War era density and aspect ratio this figure represents friction force as a function of lateral displacement and you can see in red the. Behavior of smooth surface that elso shows very prone on sticks Lee behavior and blue lines are present. Behavior or for structured surfaces and clearly we can see that it is possible to change the forces within the wide range so we wanted to know. What is the main power meter that our minds are just. So what you see here is the friction force there presented as a function of area density the area covered by the over the top apparent area and. We can see that actually air density doesn't affect friction force and this is two images from I.C.M. that suggest some explanation so when we have a different area. Then city of the projections having the same aspect ratio clearly. The normal or the is the same in both cases which leads to higher deformation when we have less elements in contact and they sealed it as a result of sure. Sure Lord and then actually that area in contact and both of the cases is a more or less the same due to the same normal law that is applied in or when. They sting the property and when that doesn't change obviously this results in the same friction force when looking at the effect of aspect ratio here we start seeing some results and clearly some optimum can be observed again it can be explained the base the. Geometry of different on the images of different surface projections here when the they or when they are high carb to rise by different stiffness and when the sheerest presses applied they bend to a different extent the surface is that a very real all keep their. Area in contact while their projections that are very high they bend and fall. And fall on or on sides so in both of these cases contact area can be quite large so frequent measured friction will be high and somewhere in the middle there exist several. German tourists when they see from this of this projections is not large and not low and they not fall aside they're not able to maintain the initial shape they just stand on the corner which results. When possible and we can see it here so it was found that aspect ratio is the main power meter that that our minds system response. And case. Projections were also started thinking about possible. That. Really beating was found in safety. So if you'll think about this device you can recognize that it consists of three different elements we have here a blade that caught the hair we have here a. Rubber. That is used to this keenly if you remember when we shave ourselves before these products come to market with one hand. Or with the other hand do we remove the here so they introduced this element that required us to have. And the result so relieving unit makes us feeling please I'm. Shaving here us the interesting thing is that this element actually stands in the condition of hydroplaning because we apply shaving form in order to wake the shaving broads with easier but this shaving form creates a lubricant layer here so the reaching the skin stretching is not really so we thought that this region is a good place where we can test our hexagonal texture they surface and we proceed in these in this direction now how we were sure that is important here if you look at the evolution of say for Tyrannosaurus you can clearly see that the number of. Why. That the found in these threatening unit is proportional to the number of blades when the generic just came to the market with their Sensor Excel they had only two blades and they have five Y. forests the next one had three blades and not in the why of why porous and what we have now. Rates based on the five blades and fifteen Y. Pers meaning that roughly saying each blade requires free wiper to have sufficient. Skin to reach. Sufficient So we wanted to test our. Rate in these units so we. We modified real safety to. We remove the blades in. Relieving units and left only. Three elements there's a schematic a presentation of the device that we that we use to test the idea this is not cutting machine this is just. A device that helps to hold save to resort to real save to resort as the one shown here with all. Elements that we didn't didn't want to test removed we test the freak show of skin straighter against the of this human skin the inner surface of the fore arm in the presence of shaving for so what do we apply the law that it was more or less similar to the one that is applied when we when we shave and there frictional force was measured with a for some sort of that moved with respect to to the him. And these are the results that we obtained trust of all this as a comparison of. By made sixth rupture and a real wipe found in saved to the. Deck of a commercially available and this is a characteristic example of friction force measured as a function of displacement C stands for commercial B. stands for by the meter so. A structure was able to generate for. Certain force when this is the core of this point it resents the instant of the onset of status lighting while tasting by magic surface in the same conditions this is the result that we have obtained it was able to generate about two times friction of. What we use in the real life safety results and this is the summary of all the results with friction Kleefisch and they represent that there is a function of surface texture and so we have here. Skins three elements. By that blade from the original materials but we had to cost similar structures from the same material because the idea was to test the effect of the geometry and not the effect of the material so we created. This same geometry based on. Material by just molding grating thin blades against the original surface and then casting these structures made from our materials and what we can learn from here is that for instance shriek shows the same friction. As a smooth surface so there is. No improvement due to surface structure of the cell. Performed illegal be better but it should. Similar results as the war matrix surface texture that we had while the best. Biometric structures performed really. Significantly better than but then. Skimmed through agers that used to know where days everywhere so after this work was published it came to us the question the way that we can collaborate on this topic so we send it to them structure us they tested them in there and eventually they told us that they're not interested which was sort of strange to me and when I started thinking about this topic I came to the conclusion that the problem was associated with this. These devices safe Tyrannosaurus are just signs to have. Designed to become obsolete because they want to sell them again and again so they don't want them to walk too well and this is the explanation so what you see here is an image of the. Safe to run it say is that roughly saying one cartridge quote will last for one month which is not C. really a logical cause them weighed from the blades are made from high speed steel. And they're called the with diamond like courting so they should be extremely where we stand it is very strange that just within one month of using against human hair or the where or so that they can to be used and probably this is the experience of most of you these devices do not hold more than just one month now. And what is the reason. Now this is the schematic. These are the blades that actually do the walk and this is a schematic a presentation of the Skins to reaching an amount that needs to have high friction now so we have high friction here which is required and we have low freq ssion here because these new. Second. As they call it guides is a cover of the by brick ation layers sort of gender that that generates floor friction and then the device separates However what happens after about a month while when this layer is removed then we have. High friction here action here skin is not raged in between these two guides and. The blades start cutting skin that creates wavy shape and off and actually this was a very interesting conclusion so in that time I had saved two rounds or that I was about to throw out because it didn't work well so I took it to the lab under the microscope and I was amazed to see that the blades of all like you saw they could steal well but the device was not not functional rated so what I did I removed the. Second element that created on the wrong side and the miracle of the device started to walk. Properly Since then I do these three little so each time I start a new save to resort and it appears that they walk about six times longer after this mall. Or pure Asian and in other very interesting result is that I stopped cutting myself because beforehand every other week I every other day I cut myself probably due to that this friction was still too high since I. Remove the element from real safety. I can do it much more safe and small. Description of how this can be done. Really simple what you need is just a safety pin that you have to stick from the back of the safe to resort and then this. Relieving unit comes out really easily so this is not true this is relieving you need for them right because this is a golden brings them golden eggs because we pay sixty. More than we should so after it is removed this is what we have and this saves to us or. Really well recommended. And this is more or less also summarize it we walked away wall shaped micro structures that able to demonstrate direction of young and around to surface roughness and a bill to generate friction we. Really high and hexagon all surface textures to prevent either playing when the brigade conditions they able to eliminate stick sleep disturbances that are very rigid to a mental cause they cause a noise. Energy losses. Problems with the curacy and where in various devices and they're using exceptional surface texture We can also tune friction within quite a wide range and I would like to think all those who helped spawn it inspired to me and helped to run all these. Tests and of course. That participated in finding these long. You know research. And thank you for coming here. That's it. But. If we have. So few structures that should be carved terrorized by flat top then we use B D M S and we cost them against so forth that it's not going to feel prepared structures when we walk or we. Project chance that that. Come in contact with the very circle services and it is not important what we have at the bottom then we use templates that have through all paintings and then we use B.B.'s which enables us which actually sort of defies fast before the mayor gets to the other side so it is a matter of speed if it wants to cross that fast we use previous first speed is not important. When we use. When speed is not important. We use. Yes young small though so for these two materials very similar about two megabytes culls also. Well these structures are quite large to be or pureed to together with cells in the principle they can be used in contact with biological tissues so know that. The surface projections for war are involved in. Creating devices that to move inside they just see if the rock causes a from a different type of bizarrely ization the reason need for a device that can move inside our borders so yes it can be used. In contact with the biological teachers. So. We're. Very. Much longer. Here. If this is associated with that you need to drain you need to remove the shaving form in this example from the interface and it takes time. So we're actually here it is able to remove more are. Lubricant and obviously it takes more time you can see that slopes here are more or less the same so the rate of flow back on to remove all is similar but this structure of the curve more cup ability to removing. To move you more efficient. OK. Well well first of all lizards have dry systems so they don't have fluid fluid. Hair like structures found in the course they are the right so liquids are present in frogs. And. I think that its purpose is to. Generate attachment so they attach themselves to you to be Larry effects. So that's why they need liquid but you know to to grasp things and to jump but they need to have not that much liquid at the interface so they need liquid but they need to be able to adjust its amount so that's why they need these channels that help to drain lubrication out of the contact and generate height generate high friction. So texturing for high freq liquid for higher diesel or maybe not high vision but. Some gain in the.