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GENERAL INFORMATION
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Last Modified: 2021-07-08

X. Xiao, Y. Wang, D. T. Seroski, K. M. Wong, R. Liu, A. K. Paravastu, G. A. Hudalla, C. K. Hall. De Novo Design of Peptides that Co-assemble into ß-sheet Based Nanofibrils. Science Advances. (2021)

This readme file describes the data files and supplementary files accompanying the above publication.  For any further queries regarding the data files, please contact anant.paravastu@chbe.gatech.edu

Title of Dataset: De Novo Design of Peptides that Co-assemble into ß-sheet Based Nanofibrils

Authors: 
Xingqing Xiao [1] 
Yiming Wang [1]
Dillon T.  Seroski [2] 
Kong, M. Wong [3] 
Renjie Liu [2]
Anant K. Paravastu [3] 
Gregory A.  Hudalla [2]
Carol K. Hall [1]

Author Affiliations:
[1] Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA
[2] J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
[3] School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA

Date range of data collection: 2018-08-16 to 2021-03-13

Funding Source: National Science Foundation Division of Chemical, Bioengineering, Environmental and Transport Systems Grant 1743432, National Science Foundation Division of Advanced Cyberinfrastructure Grant 

Link to publication: www.pnas.org/cgi/doi/10.1073/pnas.1912810117

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DATA & FILE OVERVIEW
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+---FTIR	# These excel files contain raw and normalized FTIR spectra of peptide mixtures at conditions specified in each file.
|       FTIR_Design1,2,4,5,6_15mM_1Day.xlsx
|       FTIR_Design3_10mM_1Day.xlsx
|       FTIR_Design6_15mM_1Month.xlsx
|       
+---NMR		# This excel file contains normalized NMR spectra, Lorentzian peak fit values, and calculated linewidths and peak ratio values as detailed in the file.
|       NMR_Design1,2,4,5_Summary.xlsx
|       
\---TEM
    +---Main Text	# This folder contains TIFF files of TEM micrographs presented in the publication's main text. 
    |       TEM_Design1.tif
    |       TEM_Design2.tif
    |       TEM_Design4.tif
    |       TEM_Design5.tif
    |       TEM_Design6.tif
    |       
    \---Supplemental	# This folder contains TIFF files of TEM micrographs presented in the publication's supplemental information.
            TEM_Design3A+B_24hours.tif
            TEM_Design3A+B_7days.tif
            TEM_Design3A_24hours.tif
            TEM_Design3B_24hours.tif
            TEM_Design6A+B_1month.tif

For information regarding methods used for data collection/generation, processing, and interpretation, please refer to the Materials and Methods section in the previously mentioned publication.