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GENERAL INFORMATION
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Last Modified: 2022-11-28

X. Xiao, A. S. Robang, S. Sarma, J. V. Le, M. E. Helmicki, M. J. Lambert, R. Guerrero-Ferreira, J. Arboleda-Echavarria, A. K. Paravastu, C. K. Hall

This readme file describes the data files and supplementary files accompanying the above publication.  For any further queries regarding the data files, please contact anant.paravastu@chbe.gatech.edu

Title of Dataset: Sequence patterns and signatures: computational and experimental discovery of amyloid-forming peptides

Authors: 
Xingqing Xiao [1]
Alicia S. Robang [2]
Sudeep Sarma [1]
Justin V. Le [2]
Michael E. Helmicki [2]
Matthew J. Lambert [2]
Ricardo Guerrero-Ferreira [3]
Johana Arboleda-Echavarria [3]
Anant K. Paravastu [2]
Carol K. Hall [1]

Author Affiliations:
[1] Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA
[2] School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA
[3] Robert P. Apkarian Integrated Electron Microscopy Core, Emory University School of Medicine, Atlanta, GA 30322, USA

Date range of data collection: 2022-08-01 to 2022-08-31

Funding Source: National Science Foundation Division of Chemical, Bioengineering, Environmental and Transport Systems Grant 1743432

Link to publication: https://doi.org/10.1093/pnasnexus/pgac263

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DATA & FILE OVERVIEW
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+---CircularDichroismData # This folder contains Circular Dichroism (CD) data for all eight peptides. CD runs were done in triplicate.
|       P10_Run0.txt
|       P10_Run1.txt
|       P10_Run2.txt
|       P11_Run0.txt
|       P11_Run1.txt
|       P11_Run2.txt
|       P12_Run0.txt
|       P12_Run1.txt
|       P12_Run2.txt
|       P1_Run0.txt
|       P1_Run1.txt
|       P1_Run2.txt
|       P2_Run0.txt
|       P2_Run1.txt
|       P2_Run2.txt
|       P5_Run0.txt
|       P5_Run1.txt
|       P5_Run2.txt
|       P7_Run0.txt
|       P7_Run1.txt
|       P7_Run2.txt
|       P9_Run0.txt
|       P9_Run1.txt
|       P9_Run2.txt
|       
+---FTIRdata # This folder contains FTIR data for all eight peptides.
|       P10_FTIRdata.CSV 
|       P11_FTIRdata.CSV
|       P12_FTIRdata.CSV
|       P1_FTIRdata.CSV
|       P2_FTIRdata.CSV
|       P5_FTIRdata.CSV
|       P7_FTIRdata.CSV
|       P9_FTIRdata.CSV
|       
+---TEMdata # This folder contains the TEM images taken for all eight peptides.
|       P1.png
|       P10.png
|       P11.png
|       P12.png
|       P2.png
|       P5.png
|       P7.png
|       P9.png
|       
\---ThioflavinTdata # This folder contains the Thioflavin T data collected for all eight peptides.
        AllPeptidesThioflavinTdata.xlsx

For information regarding methods used for data collection/generation, processing, and interpretation, please refer to the Materials and Methods section in the previously mentioned publication.