Welcome to the fans forum.

The goal for
the forum is to connect biology and

technology coming to Jesus
in charge scientists

engineers particularly scientists becoming
in the area bio space you know allow

the opportunity to walk alongside with
engineers to to solve some of the R.

and D.
issues and

research challenges faced by
researchers in the area and

so very glad this sixteenth event
has all of them mentioned and

I would like to thank Director all of
brand for supporting this event for

on a regular basis I also want
to thank each one off you for

joining us today I'm going to do is
the speakers in very short and so

if you were wondering was the guy
I'm sending a regular email stricken

from lunch as it's me but
you know that's become very important for

us to know all many of you is going
to show up usually sometimes you get

ten percent of fifteen percent in a North
shows from those that register and so

this times very important for
us to know if you're going to make it so

that we can order proper lunches that's
the main goal for that with that said

I would like to thank folks who supported
this particularly when this a first

time you're doing an Emory University and
so you know we were wondering lots of

the over that there's any issues we need
to deal with that we've not seen and so

thankfully OD'ing Rand Paul
like to thank all those Emory

colleagues who promoted this event and
also like to thank you duke and.

Dennis and all of the many of my
colleagues who supported this event.

With that I'm going into the.

Office speaker for the day and

Dr Yong Day also known as
Tony ease our custom from

the Department of mechanical
engineering at Georgia Tech it is C.

it is B.S. and it must degrees in
mechanical engineering from Seattle

nationally new US cities in your city and
his Ph D.

from Carnegie Mellon.

And.

He also worked as a post talk at MIT.

At the Langer lab of the Institute for
of for Integrative cancer and

he has received numerous awards it's hard
to catalogue everything at this time but

it's medically early in a dent in your
abstract and bios feel free to go through

for each speaker's but in short I
would like to highlight the one and

I actually got it DOES new
innovator award and also N.S.F.

carrier award in twenty seventeen watch
this year congratulations Tony and

he has also filed over twenty at patent
applications worldwide including nine U.S.

patterns that tell us about his
accomplishment in the research areas

he has authored several research articles
in major journals including be on A.S.

Now don't let does A.C.S.
nano just to mention few and

also you know we now invite
him to present this topic.

On engineering microfluidic systems for
disease modeling and

nanomedicine testing the R.'s don't.

Think for.

Forward motion and well what could.

Go what I'm going to present today is.

What my lab has been doing for

four years and I join the Georgia
parent the phone the third.

Title engineered microphone and
or do them all in on them and.

We all know.

How much money we invest in
the development of drugs and

I have to in the think.

On your feet is.

So up to two thousand keen.

You can't feed your family life your
two billion dollars per year and

how many empty approval the killed
biologic drugs we are on for you.

Is not really.

Being paid where the bend the money we go.

Couple of reasons we have pretty lengthy
timeline it takes you to fifteen to ten

years for your drove to Loki and
two things I want to

focus on is two thirds of the code
is to actually create the tries to.

The people now that you and
I fail fail the and

fail Chile all the city so
we can see our our money and

we can spend there for
better drugs into a compound so

then underscores the importance of for.

Fish to be interested so
my question is how we can improve

the coast effectiveness and
pretty poller interested.

In testing to see and
if you could see a drug.

Now only focusing on those but

also Meanwhile people start to
develop HOW CAN DO you are to drugs.

To the target side we
want with me Michel you

still like this you know not
a medicine that to what people

are doing is they're creating
developing some nano scale particle and

materials and trying to or incorporate
throat imaging A.J. and targeting like a.

Show.

So we can hopefully.

DROs weird side effect.

This means this to me affair
you can target a specific road

to the location we want.

In the uprising we actually started
from one thousand nine hundred.

Like leap is.

You can get my cells and light things.

So we got a life of zones and
Peggle a the to get better.

Live in circulation and

we got forced on them by this in
cold gulp feel in nineteen ninety.

By any other side people the developer
Paula movies didn't try to be now now

days since two thousand and eleven most of
us are focusing on how we can start again.

A specific film show they'll love
different types of platforms and

trying different types of sales
in the steel is this infancy so.

Why is there even though we're
working on D.V.D.'s appreciation for

diapers disease let me show
you a cup of tea till we have.

These Not on my this in the present
anonymous and in training.

You can see that most of
them is based on life but.

Even there will we got that
in one thousand nine hundred.

Eighteen and most other although not a
particle that is also locally got the into

We've the period or some other
proteins in some other Peggle it is.

But most of studies like dozens and that's
not surprising because we developers and

first but the problem is to critique or
try yours multiplatform spatial lives.

And even though we are working on
different Highveld nanoparticle

on a materials we don't have them many yet
in.

Trials and even so
one of the reason is in only to Seldon

and Clement Hill many pharmacist and

scientists they actually criticised the
field nano medicine why because we had.

Like of to stand on the eight
thousand issue Charlie Cook per year.

We don't have them many of them in this.

Show they pointed out why we have this.

And those challenges include
low to put disability.

If you show a certain drug for
fun and anonymous advocacy in vitro

did that individually guarantee that you
can show the minimal even though you show

the in the wall that doesn't guarantee
you can't show there you could try it

the problem is we are going to spend
all other money in this critical tries

anymore those still on other Legion
while you're working on the pretty.

Power.

To help you understand the field a little
bit more if we see the critique or

translation steps of none of the people
synthesize and cats was intended

to imbue through the sales and then try
to optimize the competition and function.

A few to five years if you're lucky and
then if we are sure

Ailey's disguise are not going to kill
animals now we can test within one and

then was so we spend money and time which
there are other years there we can scale

this weekend up the door for
coming to triage if we are lucky so some

of the challenges are you know the areas
once you get the bench such instances.

We have bits bits bits to experience.

So even though you pipe every
Well you can again see you can

get the financial part today and
tomorrow you and I cook the same food in.

The same vein tomorrow
taste different mean and

then it's very hard to incorporate
multiple drugs in any meeting and

at the same time because he's all over
realism or just the process how can you

guarantee that you're going to get
the same performance and same function.

That's why we may have very poor
people's ability once you scale up

because you're going to combine and

into it all the benches to get
a certain amount for and most of it.

In terms of being beat so you value.

To the coacher of transfer cell
lines isn't our primary shells

show it's one of the stills so you can a
retard get assistance between performance

with the fills you want and most of
this are enough is illogical rather than

the most up to the coach and
talks if it passed.

And a very.

Very expensive ethical issues
elso crispest is in actresses

we are now going to treat and
we're going to treat human.

Extremely difficult.

In particular for me so you can really
change a certain factors to get a certain

outcome it's very hard to get very good
correlations are using be able more.

So what my lair want to do for a long
term is how we can replace the entire

process using micro system we
can start from a continuous

process in the a production
multi confidant of particles and

then we can use high throughput coach
ideation approaches individual has this

more physiological level environments
a call that we're going to chip and

then we can manufacture it is worth.

It to bits of variation.

And what I'm going to show you today is.

Probably pretty much about what
we are working on the Milan

we have a lot of collaboration together.

But there is that sense to be splitter
issues and most of the world in my lab for

four years and more progress and

I'm going to show there is about to
publish is all of the publishing.

So this is like the overview of what
we do in terms of the microfiche since

this is all not of particles that we are
synthesizing the people in our articles

and A.T.V. and the man in our particles
and their combinations are not really

things as a light was ohms but we can see
that side that that doesn't mean we cannot

so you can see they're pretty much
homogeneous e-e poor form and I.

As you can also get this one
in our community people and

out of all the bills we call not
a crystal and dogs inside and their And.

Their communication and you can see the
side uniformity of those once we create

these Coley we have we are paralyzed
microbrew platform that we can produce

through Grant pretty damning and with less
than point one pulley this is pretty.

What I'm going to focus on today's
more like how we can make H.D.L.

because we are really interested in H.D.L.
and there are carrier performance and

it's all functionality in our body because
it's a natural particle that we don't have

that and we know that each of the other
lever's fats and cholesterol for tissues

to the lever they'll kill so-called
Put up or kill people start that.

Pool So you have additionally fifty
repaired in your body we can infuse

more H.D.L. and then you can remove those
fat even though you don't have the family

period and if you have more A.T.R.
you can the movie of Magdalene returns

it's not like essentially clinically
to try or is using an infusion of H.

of the L.

fail because what people found is eighty
years no longer is good eight each of you

know if you inject this to patients in
particularly our Tuesdays and chronic

kidney disease because those patients hair
protein from which we proteins implant.

Excessively compared to healthy people so
those

functional proteins can be
sampled to each of the deal will

lose its origin are good clue as to
the function so infusion of each of the L.

surprising it doesn't
warrant treatment trials so

this is a one of the feel
my lady is working on but

reach I got to the innovative or from an
age and we're going to talk about how we

can mimic the age of the L today and
then how you can use it as your carrier.

So how can we meet the age of the L.

Ike everyone knows a point on is the.

Dawning and apolitical protein that for
each of you so we are using a fully one

and full story appears
still we have mice fail and

then a play war on the scaffold
grant this mice still otherwise

might if we don't stable but you can get
a point on grip this life of structure so

looks like a double layer Del because
you want to create double that structure

when do you get the disk with a shame once
we add any hydrophone in the true ules

because we have hydrophobic or inside you
can get a little people each of the L.

that's what's happening in
our body too once he gets.

To that fat inside from to for tissues so

we are still what we are doing right
now we are not only things aside

in each of the but we are trying to get
any potential how lucky proteins and

peptides we can incorporate into
the A.T.L. and want to be into me how.

We can get filled if we get the sort of
functional like an outside we can actually

use it I did the function even though
we have sort of functional protein with

that specific domain is bad it actually
you can utilize that function so

we are working on using more because
I actually Malaysian collaboration is

in Georgia Ted So when you take a look
at this you can we can mimic this.

And we can also see their.

Numbers the amount of clear Civil War
nature do we can incorporate using this.

Word for that and so now we're working on

incorporating different proteins empathize
into this age of their platforms and

we are going to validate that using
our microfiche insistence approaches.

So this is the.

The one.

Schematic how we can society the L.

and from my paper actually to
SA thirteen because we are more

like a food devise a reaction society and
we are actually working on invention

disclosures I'm not going to
open today unfortunately been so

what we are doing is you're using like a
fortress is inside the Michael Free flow.

So we're not really producing all
different titles on the politics in

one thing to see if at the same time we're
changing the precursors if we want to for

example golden out of crystal
inculpatory the G.P.L.

we're going to pick gold instead of cider
contemned on right so we are not going

to really be producing all these
different now probably the same time so

if we you create each of the a very well
it's going to be around nine to eleven out

of you know which is same size we have in
our body if you incorporate hydrophobic.

So if Codey is not a crystal or any
materials inside then you're going to get

a little larger of shooting out I mean
if you remove proteins Dan you're

going to get is the only eight I was
doing myself with this distribution

to a few scenes aside each of you
know if you pull the dispersion or

wide distribution meaning that year
the system leap into solution.

So what you can do.

Deliver.

In different type of a high the full B.

imaging age and the id the I.R. so

you can actually see whether you're
not a particle pick up by sales or

spit out in the solution you can also
incorporate We can also incorporate

gold on the pistol line so I was so
we can detect this using C.P.U. or M.R.I.

If we want to at the same time when
we do produce for us in Tehran and.

You can also.

Be true for example stand in for.

Crystal and for tissues that just.

Want to see used simulate your.

Macrophages with L.P.'s
then seem to steer then

we have similar performers
when we use in the studio.

And Mr they on the show you can
actually incorporate this side of

their list as well.

So we passed it previously mostly with
macrophages now we are working on wood.

And the finish and show we had best done
sure the malleable in the jail into me and

all the you can see the bees
can close to the other side so

we're pretty good only
keep her in the meal and

this is the image we can get on one
of this and one we found is the this.

Engineered H.D.
manning our particle with a play one

protein then you actually
promote activate.

The New Deal type the UNAIDS so we can get
more need to start production like same

air as the National Park Place of years
doing in our body we passed is the mutual

and we we actually fear and
see that I can one expression if we didn't

seem to mimic a condition a kind
of inflammation using Channa fall

we couldn't see anything at the beginning
but we've seen a fall halt we see this

excessive expression of
I Can one was the we and

the aging Actually it's a decrease and
there is a do dependent degrees but

we are working on this pie will work by
changing deeper into a functional protein

is and how we can actually see
the different type of functions India and

the third in two bills are working on
a point one We will see use human proof

either a fully one that's quite expensive
so we are looking at the what kind of

all the peptides a point one we made a
template we can use so our four I have is.

What we Taffy recently you can
see they're pretty similar to.

The CHENEY A P A one an R.

for and surprisingly are for have doesn't
have any similar structure to a pulley

on is motorway ten percent of a pulley
one totally different structure but

you can get pretty seamless
structure like this and

we can also get macrophage
up take a very familiar and

competition lines we can get
pretty similar competition and

the size like we start here has
put a nine to thirteen on a meter.

And surprisingly are for a.

Cluster aflat like usually does so
we found then how much we can mimic

the ape way on a proof of a teen using
the software we tested the forward or

even the four as dual carrier performs.

You can see there was two we incorporate
one of the popular drug dogs

inside we can get larger not
a particle because it takes up.

Dalton's I.

Didn't really show say
in capsule a share if.

We can figure out if you can
decrease of so viability and

you can also see in the museum This is
a nuclei It is fifty still you can see

the older male they appear to tear the a
chimp eap you want golf has a very similar

spall as we are for our dogs so
we are looking for.

How much we can actually
Mimi a pulley on and then.

When others do the effectual killing be
able to evaluate this to these we inject

their using this to normals you know
that to morrow using ages fifty sell

we actually grow that
you are in the mouse and

we actually got the images
about the bio distribution.

We could see some quite different
depending on the how much of

the we got for me well of tissue.

More significant in Wardle poly when
we use a pull you want to be able so

you can see the call of.

Each of the particles and
when we do with dogs and the a champion in

the competition section and so
we still want to work on this.

New candidate to meet
the eight we won we found

there really peptide doesn't show
really the same level of performance.

Shows or such a lot of casual so
we can still work on this and

then trying to mimic D.L.
better in in the fourth and up to the.

Implications the second topic
I want to show today is.

How we are working on actually to populate
to the Today my proficiency biology so

we are developing different
types of micro for

the devices to mimic a certain tissues and
cell environment in the future and

also if you live in shell
what I'm going to show you.

Is invent rainouts microfiche as
Illinois are for sale and one.

Point during all still one
of those to the real world.

To make the human blood brain barrier so
we have a couple other studies

in the hope that I can have
a chance to update this later.

Still like we all know Michael
angio fish will assist and so

full of chips The disadvantage
is very using prime.

So we don't have to worry about
Christmas is in actresses.

And we are trying to make a search and

condition healthy status and
disease condition same time

of year if we have a really good control
chemical indicating by going barmy and

the size that we'll have to use all of
the cells you use all other religion and

there is a huge potential you can do to.

Explore and
use induce once we get this later and

this is a war on the future hopefully
we can get this body on a chair

through that is in evidence
here into the thirteen.

So one of the popular platform we
are using in my lab is using this

tissue there platform so we are using.

A porous membrane to meal and
a culture and that there are cells and

other strong muscles in the bottom and

we can use some hydrogels to create
through the night environment.

To get a special temporal
control chemical it.

Is and steel mills and there we can see
there are drugs in our part of the target

being and deceptive performers whether
how much can actually translocate

were stored inside into still cells were
delivered to drugs in the war channel

and one of the approach we
publish is gentle use and

to do poor is a microphone as Illinois and
this is a very simple and

a feel like the Michael food device you
can culture in the seal layer in the upper

layer and you can get a little narrower
channel in the bottom cuz we have.

Open and in each side we will
change our cots patients

not a part of delivery if you want to see
the trends of patients so you can get.

Them so you can mimic at
least the center region and

also if you see really the shoe.

Stress Actually you cannot get this year's
trends change because the channel so

you need to utilize the center channel
if you want to focus on more fuel that's

a good reminder still why this is
again I called is a real time high

kind of height of the Internet of sellers
and it Billy and their permeability and

it's compatible with the music system so
you can take the images you can see all of

the poor us poor year and the membrane and
you can get in the theorem a layer

an injunction that injunction has become
in and you can you can also see that I

can why special depending on the different
chemicals and you can just you know.

And this is true what my students are
doing in the lab your fabric carrying all

the chairs and
then we came to create the Electra and

you can use a evil into to
measure the T.R. using it to get.

A kind of high throughput approach like so
we have it's on housing

way we don't have to worry
about any bubbly shoes and.

So what we did in this paper
is we found that this may be

a really good copy we can mimic Still what
about we may make the water to flow so

we can actually use and that information I
would check once you get that information

we can actually test a lot of different
on particles and medicines so

what we did is like you now and
then the by Dr one hundred dollars.

If we have to flow in our body we
have more chance to get the plugs and

the fear cells will be activated would
this different type of shoes track.

So you can see that once we got closer you
don't have flow compared to the other.

Even using the same or those are partial
like you Schimmel they can get through

the clues is like closing in the one part
and the other part of you are not going.

So you can have one in your mobile
with a potty in there to control so

we thought what if we mimic this in our
cylinder in the morning so we simply.

Simulate it or how high flow rate we need
to get the saucer to show stress and

then we get this sensor region to
two Conti five actually how much

I can one special we get if we stimulate
way this also to show stress one urge

why you want her to get the physiological
surprisingly if you reduce the frequency.

Down to ten fold and then point
on her to you really didn't get.

The I can expression so and
this is like if we make a physiological

of an effort then of an environment
they show their response but

if you change the frequency
actually didn't show and

same in significantly same similar
to the control so we are working

on how we can mimic better the PES
official conditions using this device and

now we are working on targeting and
the theorem and treating the information

using this device and using this emergency
of pens and T.R. measurement the military.

On other topics I want to show you to the.

Developing in my lab
because renters did in.

The end their goods like everyone
knows of one of the most complex

complicated that structure in our
body is multiple cells in bore

actually to maintain you in a function so
very what B.V. easy to do and it delayed

the transport of more tools what we know
is that like less than four hundred baud.

Can get in the brain or you for

your molecules people feel you
can get translight this is.

Most of the drugs you cannot really
guarantee that in print print.

So.

If we can get the meat from all the B.V.

we can model a certain disease you in from
Asia maybe a lady that would you have

trying to mimic and we can pass this it's
intros and we can trust a blueberry or

whether we can target a certain
skills inside the brim to.

Hope that we can me my aim was to use and
that can contribute to that to

think a translation so because you may
be interested in what kind of business

models Alcides has to models show there's
no really giving beats on all those

outside people who spell of time and
money and to get like really

good he beats all these two moles like
everyone knows chance well is cultural So

you can't coach and a still sells on
the top and you can coach opposing them

in the Beneath of the membrane and
you can put your that's us into bonds so

you can actually easily try coach of
the three selves we believe that.

You can create the blues and believe that
the problem is the size not really sure

the recruiting tutti if you want to made
it where the environment show even though

you can measure the T R and the tight
junctions in brain space being the seal

sales deal is now really feel as good of
an end you don't have actually just to see

it and the fit that's connection between
the sales and S.S.I. which we can see in

the bill to be minimal speak I'm all you
can make a direct contact with the problem

is this is not we having our brains
fell you can get all the information.

From US Fed only them all if we're
interested in what's happening if they

have died content one or
not a show of Vanderbilt

researchers there the Vaio John Weeks
who they created this.

This cloture using your eyes and
all the cells needed for

a balloon barrier and
they clear this into Sergeant.

Teen one problem in this
mall Harris one challenge

is the closure one then
collision wise and.

The mature we have in the brain and
it's in now on to create a search and

in from the tree see all what is necessary
I want to show they're in a minute and

grew from balsa and it created a cool
culture but that's why culture but

this is like the fickle culture
they really get data N.T.R.

The problem is they use also
collision want to get the room and

one of the reason people really
want to use caution one this.

To get the room is structure and theory of
the year thank you if you have a subtitle

jail is very hard to get you must talk
to it in the sales so they're used to

uses and this is like five and if I can
meter is not really a micro vessel so

those are two and even larger scale and
recent paper this year the Polish and

the seal sell microvascular with
death on site and they show and

the fear but the use it out brain
specific cells a little bit.

In other than environment so

what I want to focus on to
this just two Part one is the.

One is how important is
through the environment years.

From literature you can see that
after a sign she liked it and

Michael awful issue to be right this
why are you quite sure this is three D.

If you can mimic the through the
environment you can refuse the powerful as

a condition for example G.

fat is a well known biomarker for
us to say but

if you have to hide energy feet
to fat meaning that you're after

a safe activity by one of the other
Banty's you can get using this or

larger approaches you can mimic them all
healthy system and disease system so

you can compare if you use
some like psychological.

There will be all the time activated so
you're not going to get healthy.

And Michael there too well you're
not going to get really good.

And then healthy shape if you coach or
this into the end.

Of an environment so we're actually
using our micro features of them only to

afford or and
how we can meet at the end barriers show

this is like a very beautiful schematic
you know of us care unit structure.

With on your own and if you focus and
certainly you can see

this kind of structure we have in the site
and based membrane between these two and

after say Mike that we
are equal culture together so

we are using this double layer micro
to transfer the millionaire and

with two side channels are being called
Play hydrogen in the bottom of your child

so we can actually get through the cell
network and more physiological Irvan is

just a matter unlike a very structured and
controlled the shoes to profile so

this is what we got and I mean do this and
then move quickly she'll be

within the seal cells so you can
get in the still cells and Jose and

we can come find a gel with this of
distention Dr physics in the lower chamber

so this is the really hot
images we go in in a month and

then you can see actually do cry.

Complex structure you can get
at the end assume a layer and

as the saying The Lord chambre and
you can see their structures very well.

Branching process is designed branching
processes and then you can also see their

connection with the AAPL layer the base
membrane and one of the key par for

the hydrogen all we use into which
Amber is we are using Conley real.

Or using magic combined
with telephones is this.

More like what we have in
our brain in such a matter

if compared to collision one so
we are using

the Mets as your intention see which
is show there actually little more.

Expression G.'s special of this old
is reactive the system markers answer

the question so we can actually make
better health the brain builds a billion

more than using this hydrogen and you can
also see that there differ on the full G.

when you purchase the sign
into the in three D.

L.
So Michael Kocher this into the in

three D.

So we are using math test you see
coming Asian right now to build is and

I SHOW US Army just so
we turn four in this chair so you can

see from top you understood Tai junctions
and passed and asked us Michael E.

in the lower chamber and also parasites
the side and you can see the end this is

still for the hallway as we focus
on there on the bottom and you can

see the ethyl side very Dan's structure
and that's world in the lower chamber.

Which is quite different from what
you saw in the two structures.

From view you can see the.

Feel the year the top and
then a sign in the beneath like we did.

And you can get this astral
saw in that structure and

fear we can also stain a coat for

him for we choose express when
the content within the cell layer in.

Blue invasion.

So this one is the and this is a special
edition once you culture in the field so

with this brother member yourself you
can actually specialized knowledge in

expressions for example junction of
proteins high junction proteins and

also transport a good one and
I P one which is important for

I'm a little bit of legalese so we get
pretty high expression way into still

sells a was so we try cloture this still
weird the growth of embryo cells come.

There are two to the Mormon Church.

And I'm going to quickly show what we
are doing in terms of manufacturing so

we have one of them although we published
recently is like of water small we created

the people not a particle Zwi Pell lie
that is we use a sea of people and

there we can get the best mixing
efficiency each of these micro reactor

we actually show there we are and
we can change in years still we create.

A gasket based.

Free chair machine and

if we can get this really close of play
to control you can see how we can get

a better control with using our cost of
pushing control compared to the pumps and

we can also get the stable response and
with this device we can get pretty good

control distribution on a particular evil
we manufacture in our party compared to.

Control once we have disturbance so

we really get in on the particle
distribution compared to the more.

And paralyzed we have a little wider
distribution of steel we can work on this

to get better but you can see pretty
dense concentrated concentrated H.D.L.

and they're performers by activities
field there so we're manufacturing now so

we are a little bit in the last to me
because Paul is looking at the retiree's.

This is the desired is.

For to you how the war for

my little members I really
appreciate their dinner at Ford and

my sponsors and my collaborators and
back for a time in history Thank you.

And I take some questions.

You mentioned yes

nine to eleven on a meter if you will.

So if

I understand your question correctly so.

There are each of the we have a nine
to eleven you know side if we get.

Within the core then defies is up
to twenty even thirty now I mean.

So if you talk about how I
can do produce to the brain

reduce aside depends on
the issues that your question.

A.T.L. is known to cause the bloomin data.

If.

I think there is the pending issues but
I don't think each of the L.

is really going through between sales.

Because he started in four
hundred dog show they're using

to step through media transport like you
want it in are using edge of the setters

they have the binding domain so
they can get like a Trojan

horse so
it's not like workflow to the brain but

was to get in and also to be in there and
if you have a pool of yell in

the brain dig can really contribute
to cleared I and I live and.

Out of the brain show you how do
you homeostasis some reason the way

from the truth in the brain but side like
even though you have a nine to eleven and

you cannot really get into the brain
just based on this that you.

Did answer.

So the deal that you know you use is
that since Size Me a lab or yeah yeah.

Yeah I have those casual even though I
sure like to give Ariz A lot of people

ask me those are now Paul you've got
fantasizing you know we are senseless and

I'll call you a not purchasing H.D.L.

we're projecting peptide the precaution
for you one other pep talk.

Time and then Fisher side because.

We can actually develop level we can
create a platform with different time warp

sions that's why we're doing the more
good dynamics to create another type of

platform which was not shown before and
these are in the range of what can or

Dalton is at the range of
molecule of a dollar I mean so

I like trying to kill a dog I
need to prove a point why we.

Be hundred is like.

Yeah I remember Bill Like
hundred two dogs and.

So that's why L.D.L. is larger than a.

Brain by.

Any of the questions if there are no
question let's thank Tony one more time

thank you.

No not to press in this moment or
in opposition of his time coming here and

present in this work at not offense for
Tony this is for you and

just try to change the model of
that I hope you can have it so

thank you thank you so much appreciate it.