Well.

I gave my name is Phil Sub-Zero
today I'm going to present about

the location for
new new Natal arc reconstruction.

This is a basic background
information every year.

Two Out up thousand babies are born with
a single fan trick or her defect and

approximately one third of them are
selected with plastic left her syndrome.

Two prevailing characteristics up this
syndrome aids are underdeveloped left

ventricle and under developed a or as you
can see here deceased a hyper political.

This hyper plastic The has to
be reconstituted in this form.

To rest toward the flow in the body.

Otherwise baby serving the guy so

that surgery has to be done in
the first few couple of weeks.

So to perform the surgery

the blood flow in the body has to be
totally stopped for about thirty minutes.

And if.

Because up that the patient's body
temperature has to be decreased to about

eighteen degrees Celsius.

That is gone because in order to
reduce the cell metabolic rate and

prevent should damage.

So the cells in the body
can withstand that.

No blood flow for about thirty minutes
if it is supplied with cold blood.

If that doesn't happen if the proper
perfusion the proper for sure.

Perfusion the bot it issues with cold
blood that if that doesn't happen then

a serious consequence such as brain brain
retardation or even comma can occur.

So how do you supply the cold blood.

You do that by inserting cannula

to some of the pre preferred
locations typical of patients

are doctors and
jugglers to Clave in arteries.

So you inserted and supply the blood.

The question is that nobody really knows
the impact up to come to a location and

blood flow distribution in other words.

We do not know how to use location a fact.

How much blood flows to the each that's.

That is significant because if you.

If so if some locations doesn't provide

enough blood to let's
say Head Neck vessels.

It's not it will lead to improper
perfusion of the brain cells and

will lead to brain retardation and so on.

So the objective of the study is to assess
the impact of different Arctura can

location on blood flow to use relation to
the brain using competition of dynamics.

So this is the geometry
that we used this is

more like a real model you
have a high political.

And this is all air tight regions and
this is idealized model.

As you can see here desist a hypo
plus to get you have three.

Let's test supply blood
to head up her body and

you have pulmonary arteries that supply
a blow to the lungs and descending

at least to the bottom part of the body
the system flow chart at the methodology.

We started with the hyper
plus to the idealized model.

Performed cat or computer aided design.

To insert different locations.

That has been used by clinicians and
perform C.F.D.

to measure the impact up a can do
a location of fluid distribution and

here we could apply flow
boundary condition or

in other words we didn't we
didn't not impose values such as

some person goes to which let's instead we

perform resistance boundary
conditions in this way we could

apply every system by use
to each pair to Al let's so

we can imagine how much blood
flows to each area of talents.

Now the master if I must study so mash
the definition of MASH is the vertices or

faces that make up
the shape of the three D.

pulley he threw objects in CAD and
basically

if you have more mash elements you can
come up with a more accurate model.

But on the other hand if you
have if the mash elements

increase to increase is too much.

And the simulation time or

see if the simulation time
increase dramatically as well.

So we want to find the optimized
probably probably for

that achieved both accuracy and
efficiency of simulation.

So this is still low
conditions we apply it.

And this model.

And the results indicate
that pacing mash spacing

value zero point three is optimal so we
chose that spacing to run the simulation.

And the resistance boundary conditions
again this is the purpose of this study.

Was to figure out.

Resistance values that lead
to target flow splits.

So this target splits is

the flow distribution
in the normal neonatal.

So if we figure out resistance
that lead to the target.

We could apply that to
our per month models to

measure of the low distribution.

So this is resistance by use
red that we came up with

this study was totally trial and
error method.

So we started with the arbitrary
values and came up with the spa use.

And the this is the actual flow splay
we achieved and we determine that these

actual and target values are really
close to each other so that East.

Values are.

A group acceptable to be used.

So these are the.

Different models we tested.

We inserted the inserted a can
you learned that doctors.

We inserted a cuddle and
nominee region with the different angles.

Here we used to come to Los
instead one and desist.

This is actually a combination of
doctors and a number one model.

Now we object if they wish
to ensure that all tissues

are properly profuse with an emphasis on
the brain so brain is the priority and

good perfusion and normal distribution
are taking this so called Center.

And we want to achieve the target
value because we assess.

That nature does things.

Well.

In other words.

Flow distribution in normal
neonatal body is best for

the whole neonatal intends.

So.

Now this is the result part we colored.

Different news different color scheme to

represent the different
parts of the region.

And this model up to some modal
where we inserted a cuddle and

that's this region achieved.

LORDAN normal experimental flow
flow splits in D.C. regions.

This indicates that per party including
brain will not receive enough blood.

Now the next resists
result is a one model.

The kind of lace here it is inserted weird
hyper plus to me it's really in a region.

This result shows that.

This is not mean that best soul
receives hired in the rubble and

dispersal if she receives
the Lord in the room.

Now for.

Dr split tsunami one model where
we used to come to us receive it

resulted in very close to normal use as
you can see these bodies are all similar.

And feet.

Look at the floor distribution
at each trial a serf ace.

We see that this kind of law is mostly
responsible for supplying blood to

the hand that best vessels as you can
see here mostly rat purple and orange.

And this.

Vessel is responsible or responsible for

the low flow to the to pull their
arteries and to descending air.

So we see a very.

Divide it will for each until now.

P P A bending is it's a procedure where

the clinical doctors clamp
to to pull out a release.

To increase blood flow to the had had
the vessels or to the upper part.

So it clearly affected.

Flow distribution and simulation conducted
using the same resistance as before.

For the system in our case for
imposing zero flowed through the.

So it resulted in like this.

So initially without before there was
blood flow to deep to pulmonary arteries.

But now because these two
arteries are clamped down or

more like a true treat as a wall.

There's no blood flow.

Well it will definitely increase blood
flow to the all parts of the air.

Obviously.

And that will which will lead to more.

Higher chance of perfusion
in the brain area.

Now this is a graphical
comparison of the distribution.

We see that this is the target value and
we don't want the lore.

Because Laura means less
perfusion on the brain.

So we want very clear devalues
close to do target values and

we see that doctors plus one.

Dr split tsunami that one model and the
same model with P. eight ending are cheap.

The value and the pressure and
waltz your stress magnitude.

This is this world's study in order to

find max pressure and

Max Walsh tourist magnitude and
importance of this is this is that

true true high pressure and
well sure stress magnitude

caused by blood flow from the can
lead to damage on the vessels.

So we want to have Laura values.

And the result shows that doctors
plus do not mean they will model and

that's a model with
being achieved at least.

Max pressure and Max Walsh arrests values.

So those two goals were
qualified as a good model.

Now the conclusion is that
using the methodology.

You see in this city.

It is possible to evaluate the flow
split up the high performance to current

model but not really limited
to that model any model for

any model full splits
can be a magic word and

the result part best results
obtained using choose

one to talk to send one
to nominate Cindy or

to and because the reason is
because our place was really

close to the normal physiological values
and lowest pressure and sure stress

level was were cheap which will minimize
the chance so damaging the vessels.

Now impact of P. bending.

That it will definitely increase
the blood flow to the brain.

But if targets can be
achieved without peer bending

it is such as to to not perform P.
a pending because

based on the assumption that the match for
all the Is are best.

So I want to acknowledge
my car defense cliff.

Lee mechanics lap and also presidents and

their great to research a word for
financial aid.

Thank you and your questions

yet you do most of the with without
any of these things in there with

just a standard fluency with
the pressures as well as yours receive

what is an average your here
is pressure vessels average.

So these are devalues based on
pet passed the best Pascal unit

will definitely these three
models have higher pressure and

Walsh are stressed because this low
is concentrated in one can your love

and well I guess your question
is how did I measure depression.

My question is did you look at it.

What is it without and you can do it in
there with you when you are regardless

of which type you would be OK

yeah I will tell there will
be a spike in any location so

you feel if you insert a color because
the float just impinges on the festival.

Yeah.

So it's indicated but
this rad regions will.

Happen regardless really be
a certain kind of look but it's

this was a good description.

That indicates.

If you used to come to
us the flow is divided.

So you have you yield
the last pressure and all.

Sure.
Stress.

Well

that's really can really know death.

The medical doctors do ph
bending because they think that.

Well if you do.

P.P. if the ending what happens is you're

not perfuse singalongs because
the pulmonary arteries already

supply blood to the lot blood to the lungs
but they think that for thirty minutes.

It is not bottle relieved
bottle to perfuse the lungs but

the priority is brain.

But.

There's no information on a pending
versus not P.A.B. ending and like

salt survival rate corresponding survival
rate around us anything like that.

So we really don't know.

Doctors some doctors do that just
there just so their preference.