Biomechanical Characterization of the Human Tricuspid Apparatus

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Stewart, Cheyenne Victoria Josephine
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Tricuspid regurgitation is a form of cardiovascular illness that affects over 1.6 million people in the United States. This condition is more often discovered once it becomes symptomatic, which is usually much too late in its progression and indicative of poor prognosis in the patient. Medical approaches to address this issue typically involve surgical intervention or transcatheter repair and replacement therapies, but there is still a significant lack of knowledge on how current treatments affect biomechanical characteristics of the tricuspid apparatus in humans. This study aims to provide biomechanical data surrounding the human tricuspid valve, including leaflet biaxial tensile response and chordae tendinae uniaxial failure testing response. This data will provide further insight as how to characterize the tricuspid apparatus and inform engineering decisions in future transcatheter valve therapies to address tricuspid regurgitation and improve patient prognosis. Human tricuspid leaflets and chordae are compared to previously tested porcine data. Resultantly, both species share some morphological similarities. However, human leaflet mechanical data recorded in this study exhibited statistically different trends between leaflets compared to porcine data, further emphasizing the need for additional work using human samples in investigating engineering solutions for heart valve disease.
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Undergraduate Thesis
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