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Author(s)

Authors

Advisor(s)

Advisor(s)

Editor(s)

Associated Organization(s)

Organizational Unit

Georgia Institute of Technology

Series

Series

Georgia Tech Patents

Collections

Research Publications

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Permanent Link

http://hdl.handle.net/1853/57261

Abstract

Novel quaternary pyridinium compounds useful in inhibiting acetylcholinesterase in mammals of the general structure: or pharmaceutically acceptable salts thereof, where R5 is pentafluorophenyl, phenyl monosubstituted with K, phenyl disubstituted with K, phenyl trisubstituted with K, or naphthyl; R6 is H, C1-6 alkyl, phenyl, pentafluorophenyl, phenyl mono, di, or trisubstituted with K, C1-6 alkyl with an attached phenyl group, C1-6 alkyl with an attached phenyl group mono, di, or trisubstituted with K; K is halogen, COOH, OH, CN, NO2, NH2, C1-6 alkyl, C1-6 fluorinated alkyl, C1-6 alkoxy, C1-6 alkylamine, C1-6 alkyl--O--CO--, C1-6 alkyl--CO--NH--, C1-6 alkyl--NH--CO--NH--, C1-6 alkyl--NH--CO--O--, C1-6 alkyl--NH--CO--, or (C1-6 alkyl)2 N--CO--; X is OH, C1-6 alkyl--NH--CO--O--, (C1-6 alkyl)2 --N--CO--O--, C1-6 fluoroalkyl--NH--CO--, or (C1-6 fluoroalkyl)2 --NH--CO--O--; and B is H or C1-6 alkyl.

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Date Issued

3/10/1998

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Text

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Patent

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