Title:
Complete genome sequence of Candidatus Ruthia magnifica

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Roeselers, Guus
Newton, Irene L. G.
Woyke, Tanja
Dilly, Geoffrey F.
Meredith C. Fisher
Lau, Evan
Richardson, Paul M.
Saunders, Elizabeth
Wu, Dongying
Cavanaugh, Colleen M.
Auchtung, Thomas A.
Dutton, Rachel J.
Fontanez, Kristina M.
Stewart, Frank J.
Barry, Kerrie W.
Detter, John C.
Eisen, Jonathan A.
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Abstract
The hydrothermal vent clam Calyptogena magnifica (Bivalvia: Mollusca) is a member of the Vesicomyidae. Species within this family form symbioses with chemosynthetic Gammapro-teobacteria. They exist in environments such as hydrothermal vents and cold seeps and have a rudimentary gut and feeding groove, indicating a large dependence on their endosymbionts for nutrition. The C. magnifica symbiont, Candidatus Ruthia magnifica, was the first intracel-lular sulfur-oxidizing endosymbiont to have its genome sequenced (Newton et al. 2007). Here we expand upon the original report and provide additional details complying with the emerging MIGS/MIMS standards. The complete genome exposed the genetic blueprint of the metabolic capabilities of the symbiont. Genes which were predicted to encode the proteins required for all the metabolic pathways typical of free-living chemoautotrophs were detected in the symbiont genome. These include major pathways including carbon fixation, sulfur oxi-dation, nitrogen assimilation, as well as amino acid and cofactor/vitamin biosynthesis. This genome sequence is invaluable in the study of these enigmatic associations and provides in-sights into the origin and evolution of autotrophic endosymbiosis.
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2010
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