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Biomaterials to Program Cells in situ

2012-09-13 , Mooney, David J.

There are hundreds of clinical trials of cell therapy currently underway, but simple cell infusions lead to large-scale cell death, little control over cell fate, and a typically poor clinical outcome. We propose biomaterials to first serve as cell carriers or attractors of host cell populations, and then serve to program the cells in vivo and ultimately disperse the cells to participate in regeneration or immunotherapy.