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NanoFANS Forum

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Author: Brand, Oliver × Start date: 2008 × Item Type: Publication × Type: Moving Image ×

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Now showing 1 - 4 of 4
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    NanoFANS Fall 2017 Forum: Introduction
    (Georgia Institute of Technology, 2017-10-19) Brand, Oliver
    Introduction for the Fall 2017 NanoFANS Forum.
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    NanoFANS Spring 2017 Forum: Introduction
    (Georgia Institute of Technology, 2017-05-03) Brand, Oliver
    Introduction for the Spring 2017 NanoFANS Forum.
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    NanoFANS Spring 2016 Forum: Welcome
    (Georgia Institute of Technology, 2016-05-25) Brand, Oliver
    Welcome address for the 14th 2016 NanoFANS Forum.
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    Mass-Sensitive Biochemical Microsensors
    (Georgia Institute of Technology, 2008-10-10) Brand, Oliver
    A resonant microsensor platform based on disk-type microstructures vibrating in an in-plane resonance mode for chemical and biochemical sensing applications in gas and liquid environments is presented. Based on measured short-term frequency stabilities of 1.1 10^-8 in air and 2.3 10^-6 in water, mass detection limits in the low femtogram and sub-picogram, respectively, are achieved. In a biosensing application, biomolecules are immobilized on the resonator surface. Upon selective binding of analyte molecules (e.g. via antibody-antigen binding), the mass of the resonator is increased, resulting in a measurable decrease of its resonance frequency. The feasibility of liquid-phase biosensing using the disk resonators is demonstrated experimentally by detecting anti-beta-galactosidase antibody using covalently immobilized beta-galactosidase enzyme.