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NanoFANS Forum

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Clues from Digital Radio Regarding Biomolecular Recognition

2008-10-10 , Hunt, William D.

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Medical Micro- and Nano-Technology: Case Studies in Transdermal Drug Delivery

2008-03-14 , Prausnitz, Mark R.

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Mass-Sensitive Biochemical Microsensors

2008-10-10 , Brand, Oliver

A resonant microsensor platform based on disk-type microstructures vibrating in an in-plane resonance mode for chemical and biochemical sensing applications in gas and liquid environments is presented. Based on measured short-term frequency stabilities of 1.1 10^-8 in air and 2.3 10^-6 in water, mass detection limits in the low femtogram and sub-picogram, respectively, are achieved. In a biosensing application, biomolecules are immobilized on the resonator surface. Upon selective binding of analyte molecules (e.g. via antibody-antigen binding), the mass of the resonator is increased, resulting in a measurable decrease of its resonance frequency. The feasibility of liquid-phase biosensing using the disk resonators is demonstrated experimentally by detecting anti-beta-galactosidase antibody using covalently immobilized beta-galactosidase enzyme.

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Microfluidics for Magnetic Bead Based Biosensors and Modeling of Dielectrophoresis in Nanobelts

2008-03-14 , Hesketh, Peter J.

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Analyzing Biological Cells with Micro/Nano Engineered Systems

2008-03-14 , Frazier, A. Bruno

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