Understanding Enzymes: Protein Conformation Coupled Catalysis

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Author(s)
Hammes, Gordon G.
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School of Biological Sciences
School established in 2016 with the merger of the Schools of Applied Physiology and Biology
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http://hdl.handle.net/1853/32761
Abstract
The role of conformational changes in enzyme catalysis will be discussed. A model will be advanced consisting of conformational ensembles and multiple reaction pathways to explain the incredible catalytic efficiency of enzymes. The results of ensemble and single-molecule experiments obtained with dihydrofolate reductase will be presented that support this model.
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Date
2010-03-23
Extent
72:10 minutes
Resource Type
Moving Image
Resource Subtype
Lecture
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