Impact of 40-Hz Flicker on Cellular and Molecular Pathology in a Mouse Model of Alzheimer's Disease
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Green, Briston G.
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Abstract
Alzheimer’s Disease is a progressive neurodegenerative disease that impacts 25 million people globally. Past therapeutics have targeted cellular or molecular components of AD pathology, which has proven to be widely unsuccessful. Our group utilizes 40-Hz multisensory stimulation to entrain gamma oscillations and impact AD pathology at the circuit level in 5XFAD mouse models of AD. This treatment has been shown to impact neuronal circuit function, amyloid-beta load, and microglia recruitment in the hippocampus of 5XFAD mice. This study focuses on free-floating amyloid and microglia number of mice who received 40-Hz or random treatment over seven days. We hypothesized we would see a decrease in amyloid levels and an increase in microglia count, however, we found no significant change in either metric between groups. The tissue in our study came from mice who were used in behavioral and electrophysiological recordings. Because this treatment has been repeatedly shown to cause these cellular and molecular changes, we believe the behavioral training and electrophysiological recordings influenced these metrics in a way that confounded our experiment.
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Undergraduate Research Option Thesis