Comparison of craniotomy versus craniectomy methods for studying intracranial pressure increases in rats for traumatic brain injury models

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EDWARDS-UNDERGRADUATERESEARCHOPTIONTHESIS-2014.pdf (291.5 KB)
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Edwards, John Lukas
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Wallace H. Coulter Department of Biomedical Engineering
The joint Georgia Tech and Emory department was established in 1997
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http://hdl.handle.net/1853/53760
Abstract
Traumatic brain injury (TBI) is the leading cause of death for people under the age of 45 (Gabrielian et al, 2011). One of the most troubling problems for physicians in treating TBI is increased intracranial pressure (ICP). ICP is the pressure the brain and the cerebrospinal fluid exert on the skull. In a study consisting of TBI patients, 54% of them had increased ICP (Rangel-Castillo, 2008). Experimental studies show variable results, with some injury models exhibiting a significant increase in ICP whereas others do not. This controversy calls for more research to clarify under what conditions experimental TBI mimics the ICP changes that occur clinically. One of the difficulties is that the methods in which ICP is measured are variable, or are not detailed enough to compare from study to study. For example, the methods do not detail, during open head injury, whether the bone flap is replaced (craniotomy) or not (craniectomy). For this research study, the differences between the two methods, craniotomy versus craniectomy, will be studied to see if there is a significant difference between the two methods. The data showed no significant difference for either trial, but the results show that the data is more consistent with the use of the craniotomy.
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2014-05-02
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