Title:
Solubility and phase transitions in batch and laminar-flow tubular crystallizers

dc.contributor.advisor Rousseau, Ronald W.
dc.contributor.author Mendez del Rio, Jose R. en_US
dc.contributor.committeeMember Angus P. Wilkinson
dc.contributor.committeeMember David J. am Ende
dc.contributor.committeeMember William J. Koros
dc.contributor.department Chemical Engineering en_US
dc.date.accessioned 2005-03-01T19:37:09Z
dc.date.available 2005-03-01T19:37:09Z
dc.date.issued 2004-12-03 en_US
dc.description.abstract The research addressed in this thesis focuses on monitoring and characterization of pharmaceutical compounds by laser backscattering. In particular, this study covers two topics: (1) the determination of naproxen sodium solubility in water, and its phase transition; and (2) comparisons of batch and laminar flow tubular crystallizers for the production of paracetamol (acetaminophen) and D-mannitol. Using a Lasentec™ Focused Beam Reflectance Measurement (FBRM) device, the solubility of naproxen sodium in aqueous solutions was determined over a temperature range from 15.2 to 39.7 ℃ With the determination of the solubilities of two pseudopolymorphs, anhydrous and dihydrated naproxen sodium, the phase transition point between these two forms of the pharmaceutical compound was determined to occur at 30.3 ℃ Enthalpy of solution and metastable zone widths were also determined for the experimental conditions. Crystallizations of paracetamol and D-mannitol were performed in a batch crystallizer and in a laminar flow tubular crystallizer (LFTC) system. In the latter system, supersaturation was generated rapidly in the solution being transported through a temperature-controlled tube and recovered in a batch vessel where product crystals were grown to equilibration. Because of the rapid rate at which supersaturation was generated in the LFTC, the resulting crystals were of smaller mean size than those obtained from batch crystallizations. The total time required for crystallization was significantly less with the LFTC than with the batch unit. Additionally, the rapid cooling in the LFTC led to the formation of two different polymorphs of paracetamol, Forms I and II. en_US
dc.description.degree M.S. en_US
dc.format.extent 1997179 bytes
dc.format.mimetype application/pdf
dc.identifier.uri http://hdl.handle.net/1853/4876
dc.language.iso en_US
dc.publisher Georgia Institute of Technology en_US
dc.subject Acetaminophen en_US
dc.subject Paracetamol
dc.subject Naproxen sodium
dc.subject D-mannitol
dc.subject Batch crystallizer
dc.subject Polymorphism
dc.subject Laminar-flow tubular crystallizer
dc.subject Solubility
dc.subject Pseudopolymorphism
dc.subject Lasentec FBRM
dc.subject.lcsh Pharmaceutical chemistry en_US
dc.subject.lcsh Solutions, Supersaturated en_US
dc.subject.lcsh Acetaminophen en_US
dc.subject.lcsh Lasers in biochemistry en_US
dc.subject.lcsh Naproxen Solubility en_US
dc.title Solubility and phase transitions in batch and laminar-flow tubular crystallizers en_US
dc.type Text
dc.type.genre Thesis
dspace.entity.type Publication
local.contributor.advisor Rousseau, Ronald W.
local.contributor.corporatename School of Chemical and Biomolecular Engineering
local.contributor.corporatename College of Engineering
relation.isAdvisorOfPublication 54a1d094-6cef-41c7-8168-e36b41eaf4f7
relation.isOrgUnitOfPublication 6cfa2dc6-c5bf-4f6b-99a2-57105d8f7a6f
relation.isOrgUnitOfPublication 7c022d60-21d5-497c-b552-95e489a06569
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