Title:
Microgel Based Materials for Controlled Macromolecule Delivery

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dc.contributor.advisor Lyon, L. Andrew
dc.contributor.author Nolan, Christine Marie en_US
dc.contributor.committeeMember Beckham, Haskell
dc.contributor.committeeMember Bottomley, Lawrence
dc.contributor.committeeMember El-Sayed, Mostafa
dc.contributor.committeeMember Mizaikoff, Boris
dc.contributor.department Chemistry and Biochemistry en_US
dc.date.accessioned 2005-07-28T17:55:34Z
dc.date.available 2005-07-28T17:55:34Z
dc.date.issued 2005-04-10 en_US
dc.description.abstract This dissertation focuses on utilization of poly(N-isopropylacylamide) (pNIPAm) based mirogels for regulated macromolecule drug delivery applications. There is particular emphasis on incorporation of stimuli responsive materials into multi-layer thin film constructs with the main goal being fabrication of highly functional materials with tunable release characteristics. Chapter 1 gives a broad overview of hydrogel and microgel materials focusing on fundamental properties of pNIPAm derived materials. Chapter 2 illustrates the progression of controlled macromolecule release from hydrogel and microgel materials and sets up the scope of this thesis work. Chapter 3 details studies on thermally modulated insulin release from microgel thin films where extended pulsatile release capabilities are shown. Chapters 4 and 5 focus on more fundamental synthesis and characterization studies of PEG and acrylic acid modified pNIPAm microgels that could ultimately lead to the design of protein loaded microgel films with tunable release characteristics. Chapter 6 illustrates fundamental macromolecule loading strategies, which could also prove useful in future protein drug delivery design using stimuli responsive networks. Chapter 7 concentrates on direct insulin release studies that probe the interaction between entrapped and freely diffusing protein and microgels. These model experiments could prove useful in design of tunable macromolecule drug release from functionally modified microgels and could aid in the tailored design of peptide-loaded microgel thin films. Chapter 8 discusses the future outlook of controlled macromolecule release from microgel based materials. en_US
dc.description.degree Ph.D. en_US
dc.format.extent 9360425 bytes
dc.format.mimetype application/pdf
dc.identifier.uri http://hdl.handle.net/1853/6874
dc.language.iso en_US
dc.publisher Georgia Institute of Technology en_US
dc.subject Delivery en_US
dc.subject Macromolecules
dc.subject Microgel
dc.subject Hydrogel
dc.subject.lcsh Macromolecules en_US
dc.subject.lcsh Nanoparticles en_US
dc.subject.lcsh Colloids en_US
dc.subject.lcsh Drug delivery systems en_US
dc.title Microgel Based Materials for Controlled Macromolecule Delivery en_US
dc.type Text
dc.type.genre Dissertation
dspace.entity.type Publication
local.contributor.advisor Lyon, L. Andrew
local.contributor.corporatename School of Chemistry and Biochemistry
local.contributor.corporatename College of Sciences
relation.isAdvisorOfPublication 6a99c0e3-9c1a-4564-ad17-9be174626f75
relation.isOrgUnitOfPublication f1725b93-3ab8-4c47-a4c3-3596c03d6f1e
relation.isOrgUnitOfPublication 85042be6-2d68-4e07-b384-e1f908fae48a
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