Nanomaterial-Enhanced Multiplexed High Throughput Point-Of-Care Electronic Biosensing Of Antibody Biomarkers Of Neglected Tropical Diseases
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Senthil, Mallika
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Abstract
The burden of Neglected Tropical Diseases (NTDs) and their current treatment plan - Mass Drug Administration (MDA) - is too expensive, time and personnel-intensive, and doesn’t address reinfection to be viable in the long run. Hence, a Point of Care (POC) device is needed for early detection and post-treatment surveillance of NTDs. The Sarkar lab has developed two such POC platforms in recent years: Optical and Electronic platforms. The electronic platform needed an automated impedance measurement system, so I built the Zscan to minimize measurement error and increase the overall speed and repeatability of the process. Following this, I’ve applied the POC platforms to two NTDs; Onchocerciasis and Schistosomiasis. Finally, I’ll describe the work I’ve done so far in using nanomaterials to enhance the sensitivity of the electronic platform.
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2024-04-29
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