Nanoparticle Surface Charge Directs the Cellular Binding of Nanoparticle-protein Complexes
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Author(s)
Fleischer, Candace C.
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Abstract
Nanoparticles used in biomedical applications are exposed to a host of extracellular proteins that
can non-specifically adsorb to the nanoparticle surface. We have studied how blood serum proteins can
direct the cellular binding of nanoparticles. We have determined that cationic nanoparticle binding is
increased in the presence of serum proteins, and binding occurs to a scavenger receptor on the cell surface. In
comparison, the cellular binding of anionic nanoparticles is inhibited by serum proteins and the nanoparticle
binds to native protein receptors.
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Date
2012-12-11
Extent
27:00 minutes
Resource Type
Moving Image
Resource Subtype
Lecture