Title:
From Mechanosensitive Genes and Epigenetics To Nanomedicine ‐ Going With the Flow to Develop Novel Anti‐atherogenic Therapies

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dc.contributor.author Jo, Hanjoong
dc.contributor.corporatename Georgia Institute of Technology. Institute for Bioengineering and Bioscience en_US
dc.contributor.corporatename Georgia Institute of Technology. Dept. of Biomedical Engineering en_US
dc.contributor.corporatename Emory University. Division of Cardiology en_US
dc.date.accessioned 2015-09-11T15:54:57Z
dc.date.available 2015-09-11T15:54:57Z
dc.date.issued 2015-09-08
dc.description Presented on September 8, 2015 from 8:30 a.m.-9:30 a.m. at the Parker H. Petit Institute for Bioengineering and Biosciences (IBB), room 1128, Georgia Tech. en_US
dc.description Hanjoong Jo, Ph.D. is the John and Jan Portman Professor of Biomedical Engineering, Wallace H. Coulter Department of Biomedical Engineering, Georgia Tech and the Division of Cardiology, Emory University.
dc.description From Mechanobiology to RNA-based Therapeutics and Nanomedicine: Hanjoong Jo and his lab study how mechanical force associated with blood flow regulates vascular biology and cardiovascular disease, especially atherosclerosis, aortic valve (AV) calcification, and abdominal aortic aneurysms. His lab developed a mouse model of flow-induced atherosclerosis and in vitro shear stress systems to understand the role of flow in endothelial cells and atherosclerosis. Using the animal model, his lab discovered numerous mechanosensitive genes (mRNAs and microRNAs) that are regulated by disturbed flow and their role in atherosclerosis and AV calcification. Recently, his lab has shown that disturbed flow regulates mechanosensitive genes by controlling epigenomic DNA methylation patterns and that inhibition of a key enzyme DNMT by 5-Aza-deoxycytidine can prevent atherosclerosis in mice. His lab has begun taking steps to translate these animal studies toward the clinic by developing better gene and drug therapies using nanotechnology-based delivery approaches and better therapeutic strategies.
dc.description Runtime: 54:55 minutes
dc.embargo.terms null en_US
dc.format.extent 54:55 minutes
dc.identifier.uri http://hdl.handle.net/1853/53817
dc.language.iso en_US en_US
dc.publisher Georgia Institute of Technology en_US
dc.relation.ispartofseries Petit Institute Breakfast Club Seminar Series
dc.subject Atherosclerosis en_US
dc.subject Distrubed flow en_US
dc.subject Epigenetics en_US
dc.subject Mechanosensitive genes en_US
dc.subject Targeted anti‐miR delivery en_US
dc.title From Mechanosensitive Genes and Epigenetics To Nanomedicine ‐ Going With the Flow to Develop Novel Anti‐atherogenic Therapies en_US
dc.type Moving Image
dc.type.genre Lecture
dspace.entity.type Publication
local.contributor.author Jo, Hanjoong
local.contributor.corporatename Parker H. Petit Institute for Bioengineering and Bioscience
local.relation.ispartofseries Petit Institute Breakfast Club Seminar Series
relation.isAuthorOfPublication 7eb8fb49-de34-4fc6-aea8-80b31a2a2be8
relation.isOrgUnitOfPublication d978f252-ad5a-4fe6-a735-21050b2d760e
relation.isSeriesOfPublication 037a6ee9-c6f0-4f20-abb8-e229d98f6754
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