Title:
Gastrointestinal Motility: Kinematic Properties of Segmentation Contraction

dc.contributor.advisor Hu, David
dc.contributor.author Lamarca, Morgan
dc.contributor.committeeMember Goodisman, Michael
dc.contributor.committeeMember Mendelson, Joseph
dc.contributor.department Biology
dc.date.accessioned 2018-08-20T19:10:30Z
dc.date.available 2018-08-20T19:10:30Z
dc.date.created 2017-05
dc.date.issued 2017-05
dc.date.submitted May 2017
dc.date.updated 2018-08-20T19:10:30Z
dc.description.abstract The kinematic processes of the small intestine play integral roles in overseeing the digestion and transportation of food throughout the gastrointestinal tract. Specifically responsible for governing the flow and digestion of chyme along the gastrointestinal tract are the two fundamental patterns of motility, propulsion and mixing [1]. While peristalsis is the principle muscle contraction for propulsive motility, segmentation contractions are responsible for mixing and chopping the chyme [2]. Previous studies on the contraction kinematics of the small intestine have provided evidence that contraction frequencies alter in response to different types of food. We propose that the pattern of segmental contraction varies in response to the different compositions of intraluminal contents as well. As the composition of chyme alters and it becomes less dense, segmental contraction frequency increases as a response. Our in vivo observational technique conducted on the small intestine of male Sprague-Dawley rats is much less invasive than previous studies, thus allowing us to better quantify the kinematic properties of the small intestine, such as frequency and amplitude of contraction. Understanding and comparing essential patterns of motility across patients can improve medical diagnostics as well as the manufacturing of food supplements and pharmaceutical medications.
dc.description.degree Undergraduate
dc.format.mimetype application/pdf
dc.identifier.uri http://hdl.handle.net/1853/60330
dc.language.iso en_US
dc.publisher Georgia Institute of Technology
dc.subject Gastrointestinal motility
dc.subject Segmentation contraction
dc.subject Segmentation contraction frequency
dc.subject Small intestine
dc.subject chyme density gradient
dc.subject in vivo animal model
dc.title Gastrointestinal Motility: Kinematic Properties of Segmentation Contraction
dc.type Text
dc.type.genre Undergraduate Thesis
dspace.entity.type Publication
local.contributor.corporatename College of Sciences
local.contributor.corporatename School of Biological Sciences
local.contributor.corporatename Undergraduate Research Opportunities Program
local.relation.ispartofseries Undergraduate Research Option Theses
relation.isOrgUnitOfPublication 85042be6-2d68-4e07-b384-e1f908fae48a
relation.isOrgUnitOfPublication c8b3bd08-9989-40d3-afe3-e0ad8d5c72b5
relation.isOrgUnitOfPublication 0db885f5-939b-4de1-807b-f2ec73714200
relation.isSeriesOfPublication e1a827bd-cf25-4b83-ba24-70848b7036ac
thesis.degree.level Undergraduate
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