Title:
Synthesis and Pharmacology of Potential Site-Specific Therapeutic Agents for Cocaine Abuse

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dc.contributor.advisor Collard, David M.
dc.contributor.advisor Deutsch, Howard M.
dc.contributor.author Moore, Susanna en_US
dc.contributor.committeeMember Fahrni, Christoph J.
dc.contributor.committeeMember Margaret M. Schweri
dc.contributor.committeeMember Suzy B. Shuker
dc.contributor.department Chemistry and Biochemistry en_US
dc.date.accessioned 2005-03-02T22:17:05Z
dc.date.available 2005-03-02T22:17:05Z
dc.date.issued 2004-06-28 en_US
dc.description.abstract Synthesis and Pharmacology of Potential Site-Directed Therapeutic Agents for Cocaine Abuse Susanna Moore 235 Pages Directed by Dr. David M. Collard and Dr. Howard M. Deutsch Stimulants such as cocaine continue to dominate the nations illicit drug problem. An effective medication for any aspect of cocaine addiction has not been developed. Cocaine binds, although not selectively, to the dopamine transporter (DAT) and disrupts normal dopamine (DA) neurotransmission between neurons. While the dopamine hypothesis for the mechanism of action of cocaine has been widely accepted, cocaine also possesses the ability to block the uptake of serotonin at the serotonin transporter (5-HTT) and norepinephrine at the norepinephrine transporter (NET). The purpose of the work described herein is directed towards synthesizing and testing compounds selective for the DAT, leading to the identification of candidates as potential pharmacotherapies for cocaine dependence. A series of disubstituted and trisubstituted [2.2.2] and [2.2.1]bicycles were synthesized and tested for inhibitor potency in [3H]WIN 35,428 (WIN) binding at the DAT and for inhibition of [3H]DA uptake. Based on results from some of the pharmacology data new regio- and stereochemical isomers of bicyclic [2.2.1]heptanes and [2.2.2]octanes were synthesized. This will lead to further structure-activity-relationships, which will provide a better understanding of the structural requirements needed to bind at the DAT. en_US
dc.description.degree Ph.D. en_US
dc.format.extent 1966748 bytes
dc.format.mimetype application/pdf
dc.identifier.uri http://hdl.handle.net/1853/5010
dc.language.iso en_US
dc.publisher Georgia Institute of Technology en_US
dc.subject LR5182 en_US
dc.subject.lcsh Cocaine habit Treatment en_US
dc.subject.lcsh Dopamine en_US
dc.title Synthesis and Pharmacology of Potential Site-Specific Therapeutic Agents for Cocaine Abuse en_US
dc.type Text
dc.type.genre Dissertation
dspace.entity.type Publication
local.contributor.advisor Collard, David M.
local.contributor.corporatename School of Chemistry and Biochemistry
local.contributor.corporatename College of Sciences
relation.isAdvisorOfPublication 93732ff7-3229-47ad-ad56-7ccdae805102
relation.isOrgUnitOfPublication f1725b93-3ab8-4c47-a4c3-3596c03d6f1e
relation.isOrgUnitOfPublication 85042be6-2d68-4e07-b384-e1f908fae48a
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